{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:17:44Z","timestamp":1789550264028,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>(1) To evaluate the ability of western performance horses diagnosed with chondromalacia to return to performance; Specifically, the relationship between the grade of chondromalacia and the horses' ability to resume work; (2) To determine the impact of postoperative therapy on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Horses (<jats:italic>n<\/jats:italic>\u2009=\u200934).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of western performance horses with lameness localized to the stifle that underwent subsequent arthroscopy with chondromalacia as the most significant diagnosis were reviewed. Chondromalacia was surgeon\u2010graded as slight, mild, moderate, or marked. Three evaluated categories of postoperative intra\u2010articular therapy included: (1) bone marrow derived mesenchymal stem cells, (2) equine amniotic allograft product or (3) none. Outcome was defined as returning to previous level of work on a numeric scale (1\u201310).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chondromalacia and its degree of severity and focal vs. diffuse distribution identified arthroscopically did not show a significant association (<jats:italic>p<\/jats:italic>\u2009=\u2009.54, .40, respectively) or correlation (<jats:italic>p<\/jats:italic>\u2009=\u2009.18; <jats:italic>R\u2010<\/jats:italic>value: 0.27) with the ability to return to athletic performance. The type of postoperative intra\u2010articular therapy did not have any association with the horse returning to athletic work (<jats:italic>p<\/jats:italic>\u2009=\u2009.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A statistically significant association between severity, distribution or subsequent postoperative therapy for stifle chondromalacia and the ability to return to work was not observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>Compared to previously published reports, this study demonstrated a 74% more favorable prognosis for returning to some level of athletic work despite only 44% of horses returning to their previous level of performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vsu.14196","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:12:03Z","timestamp":1741741923000},"page":"831-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severity, distribution and postoperative therapy are not predictors of return to work in western performance horses with stifle chondromalacia"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7272-6410","authenticated-orcid":false,"given":"Angie M.","family":"Esselman","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"},{"name":"Equine Sports Medicine  Pilot Point Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Hague","sequence":"additional","affiliation":[{"name":"Rocking E Stables Equine Rehabilitation Center  Stillwater Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Frisbie","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13241"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13397"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12366"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.1821"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1997.210.11.1649"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1995.206.06.842"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1995.tb00299.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12100.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00524.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13205"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7234-3693-5.00006-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200108000-00002"},{"issue":"36","key":"e_1_2_9_14_1","first-page":"1","article-title":"Determination of reference values and frequency of occurrence of patella alta in German shepherd dogs: a retrospective study","volume":"59","author":"\u0141ojszczyk\u2010Szczepaniak A","year":"2017","journal-title":"Acta Vet Scand"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403776014163"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13784"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2001.06.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0095399703258790"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31480"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0193"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.06.042"},{"key":"e_1_2_9_22_1","first-page":"39","volume-title":"Stem Cells as a Treatment for Osteoarthritis","author":"Frisbie DD","year":"2007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20508"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2008.00462.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-08-10-0107"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20933"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11365"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01284"},{"key":"e_1_2_9_29_1","first-page":"1552","article-title":"Evaluation of intra\u2010articular mesenchymal stem cells to augment healing of microfractured chondral defects","volume":"27","author":"McIlwraith CW","year":"2011","journal-title":"Art Ther"},{"key":"e_1_2_9_30_1","first-page":"420","article-title":"Evaluation of bone marrow derived stem cells and adipose derived stromal vascular fraction for treatment of osteoarthritis using an equine experimental model","volume":"52","author":"Frisbie DD","year":"2006","journal-title":"Proc Am Assoc Equine Pract"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21366"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2011.06.005"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13918"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1696672"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40883-018-0087-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1576"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.03.022"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.14196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:52:28Z","timestamp":1753185148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.14196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/vsu.14196"],"URL":"https:\/\/doi.org\/10.1111\/vsu.14196","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,9]]},"assertion":[{"value":"2024-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}