{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:53:39Z","timestamp":1784739219800,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR056624"],"award-info":[{"award-number":["R01 AR056624"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM007170"],"award-info":[{"award-number":["T32 GM007170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2025,4]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To investigate the occurrence, degree, and risk factors associated with arthroscopic stifle joint synovitis in dogs with cranial cruciate ligament (CCL) disease.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective, observational study.<\/jats:p>\n <\/jats:sec>\n \n Sample population<\/jats:title>\n \n Canine CCL disease (\n n<\/jats:italic>\n \u2009=\u2009163) from 149 dogs and their arthroscopic video recordings.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Arthroscopic video recordings were reviewed. A synovitis severity (0\u20135) and a modified Outerbridge cartilage classification system score were assigned, along with recording the presence or absence of a medial meniscal bucket handle tear. Medical records were reviewed for age, sex, limb, and duration of clinical signs. Univariate analyses were performed via a Fisher's exact test for categorical independent variables, and ordered logistic regression was used for continuous variables. Multivariable ordered logistic regression considered independent variables with a\n p<\/jats:italic>\n \u2010value <.2 on univariate analyses.\n p<\/jats:italic>\n \u2010value <.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Synovitis was identified in 100% of the stifles examined. The most frequent synovitis severity score was 3\/5. Univariate analysis showed a significant association between synovitis severity score and bodyweight (\n p<\/jats:italic>\n \u2009=\u2009.005), median cartilage score (\n p<\/jats:italic>\n \u2009=\u2009.002), and being female (\n p<\/jats:italic>\n \u2009=\u2009.032). On multivariable analysis, the synovitis severity score was significantly associated with median cartilage score (\n p<\/jats:italic>\n \u2009=\u2009.042) and duration of clinical signs (\n p<\/jats:italic>\n \u2009<\u2009.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Synovitis was arthroscopically always identified in stifles with CCL disease. The severity of synovitis was associated with more progressive damage to the articular cartilage and a longer duration of clinical signs.<\/jats:p>\n <\/jats:sec>\n \n Clinical significance<\/jats:title>\n Earlier intervention in dogs with CCL disease may be warranted to decrease synovitis and progression of osteoarthritis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vsu.14222","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:35:01Z","timestamp":1738884901000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arthroscopic synovitis severity scoring in canine stifles with cranial cruciate ligament disease"],"prefix":"10.1111","volume":"54","author":[{"given":"Elisabeth A.","family":"Lemmon","sequence":"first","affiliation":[{"name":"Translational Musculoskeletal Research Center, CMC VA Medical Center Philadelphia Pennsylvania USA"},{"name":"McKay Orthopedic Research Laboratory, Department of Orthopedic Surgery University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania, School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Division of Biostatistics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Mauck","sequence":"additional","affiliation":[{"name":"Translational Musculoskeletal Research Center, CMC VA Medical Center Philadelphia Pennsylvania USA"},{"name":"McKay Orthopedic Research Laboratory, Department of Orthopedic Surgery University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Agnello","sequence":"additional","affiliation":[{"name":"Translational Musculoskeletal Research Center, CMC VA Medical Center Philadelphia Pennsylvania USA"},{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania, School of Veterinary Medicine Philadelphia Pennsylvania 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