{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:17Z","timestamp":1787016077948,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the utility of a saline\u2010based modified del Nido (mDN) cardioplegia solution with a conventional institutional technique (multidose St. Thomas blood cardioplegia) for mitral valve repair (MVR) in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective, randomized, open\u2010label trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty client\u2010owned dogs with myxomatous mitral valve disease (stage B2 and C) eligible for MVR were divided into control and modified mDN groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cardioplegia was induced in the control group using 50% blood containing St. Thomas solution every 10\u2009min. In the mDN group, a cardioplegia solution containing 20% blood was administered once or when required. As the primary outcome, serum cardiac troponin I levels were compared 12\u2009h postoperatively between the groups. The other clinical findings were evaluated as secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Troponin levels 12\u2009h after surgery were a median of 27.8\u2009ng\/mL (interquartile range, 15.1\u201343.2) in the control group and 19.4\u2009ng\/mL (15.2\u201333.6) in the mDN group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.478). The sinus rhythm recovery time following aortic cross\u2010clamp removal was 362\u2009s (103\u2013995) in the control group and 60\u2009s (44\u2013605) in the mDN group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027). The total amount of crystalloid cardioplegia solution required was 12.6\u2009mL\/kg (11.3\u201315.0) in the control group and 23.6\u2009mL\/kg (18.0\u201335.1) in the mDN group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cardiac troponin I levels did not show differences between the groups. The saline\u2010based mDN cardioplegia facilitated earlier sinus rhythm recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>Saline\u2010based mDN cardioplegia may be a viable alternative for canine MVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.14278","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T05:09:44Z","timestamp":1749445784000},"page":"1366-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Saline\u2010based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-7769","authenticated-orcid":false,"given":"Kentaro","family":"Kurogochi","sequence":"first","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"},{"name":"Department of Clinical Sciences North Carolina State University, College of Veterinary Medicine  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arane","family":"Takahashi","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Nii","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Chen","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Furusato","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"},{"name":"Department of Health Data Science Yokohama City University  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sugiya","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Uechi","sequence":"additional","affiliation":[{"name":"JASMINE Veterinary Cardiovascular Medical Center  Yokohama 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