{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:54:33Z","timestamp":1791366873829,"version":"4.3.1"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether perioperative management guided by conditional computed tomography\u2010myelography (C\u2010CTM) is non\u2010inferior to magnetic resonance imaging (MRI) regarding functional outcome for acute thoracolumbar intervertebral disc extrusion (IVDE) in non\u2010ambulatory chondrodystrophic dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Quasi\u2010randomized natural experiment utilizing unscheduled MRI downtime as an exogenous instrument.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample population<\/jats:title>\n                    <jats:p>A total of 560 client\u2010owned dogs (MRI, 518 dogs; C\u2010CTM, 42 dogs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted. The primary outcome was recovery of ambulation, analyzed with intention\u2010to\u2010treat (ITT) and per\u2010protocol (PP) principles with a prespecified non\u2010inferiority margin of \u221212%. Secondary outcomes included safety events (postoperative neurologic deterioration, progressive myelomalacia, major complications) and time\u2010adjusted treatment costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      C\u2010CTM was non\u2010inferior to MRI for recovery of ambulation in both ITT (risk difference\u2009+\u20096.5%, 95% CI: \u22122.7%\u201315.7%, one\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and PP analyses (risk difference\u2009+\u20092.5%, 95% CI: \u22127.3%\u201312.2%, one\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). There was no difference in rates of postoperative neurologic deterioration, progressive myelomalacia, or major complications. Total treatment costs and imaging costs were significantly lower for C\u2010CTM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). There was no difference in non\u2010imaging costs between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In non\u2010ambulatory chondrodystrophic dogs with acute thoracolumbar IVDE, C\u2010CTM is non\u2010inferior to MRI for recovery of ambulation with a similar safety profile, at significantly lower cost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>In dogs with a high pretest probability of acute thoracolumbar IVDE, routine use of MRI may not be justified given the comparable clinical outcomes and lower treatment costs achieved with C\u2010CTM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.70135","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:09:06Z","timestamp":1785492546000},"page":"1198-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computed tomography versus magnetic resonance imaging for the perioperative management of acute thoracolumbar intervertebral disc extrusion in non\u2010ambulatory chondrodystrophic dogs"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-4997","authenticated-orcid":false,"given":"Daniel","family":"Low","sequence":"first","affiliation":[{"name":"Swift Referrals  Wetherby UK"},{"name":"frank. Pet Surgeons  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Markovic","sequence":"additional","affiliation":[{"name":"Swift Referrals  Wetherby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12496"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105844"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16480"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20108261.2009.01549.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1499"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2022.100467"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2010.00936.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12700"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/neur.2023.0129"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14250"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.14\u20100582"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1454"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1438300"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14715"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e31823f2f55"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.237.10.1160"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010019\u20102186\u20100"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14656"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.596059"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12576"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.70029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.3.361"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jvimsj\/aalag016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102988"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.588338"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14089"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.70191"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.10.011"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13147"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_10_32_1","unstructured":"WickhamH Fran\u00e7oisR M\u00fcllerK VaughanD.dplyr: A Grammar of Data Manipulation. R package version 1.1.4. Published online 2023.https:\/\/github.com\/tidyverse\/dplyr."},{"key":"e_1_2_10_33_1","unstructured":"WickhamH VaughanD GirlichM.tidyr: Tidy Messy Data. R package version 1.3.1. Published online 2024.https:\/\/github.com\/tidyverse\/tidyr."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.48550\/ARXIV.1412.3565"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental\u20102020\u2010300162"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v040.i03"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.259.5.463"},{"key":"e_1_2_10_39_1","unstructured":"Competition & Markets Authority.Market Investigation Into The Supply Of Veterinary Services In The United Kingdom.2025https:\/\/assets.publishing.service.gov.uk\/media\/6846e62357f3515d9611f115\/___Extension_notice_.pdf."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.259.7.712"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2021.0290"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2024.111457"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.12.008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258\u2010024\u201000876\u20102"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzy248"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v11.i4.110"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2014.05.022"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpm.2806"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X12451550"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.974"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2009.0393.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7188"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.244"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12249"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X241257878"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2009.02.016"}],"container-title":["Veterinary Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.70135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vsu.70135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vsu.70135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:29:41Z","timestamp":1791365381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vsu.70135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/vsu.70135"],"URL":"https:\/\/doi.org\/10.1111\/vsu.70135","archive":["Portico"],"relation":{},"ISSN":["0161-3499","1532-950X"],"issn-type":[{"value":"0161-3499","type":"print"},{"value":"1532-950X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}