{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:51:11Z","timestamp":1791978671079,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Surgery"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe a novel titanium three\u2010dimensional\u2010printed patient\u2010specific radial endoprosthesis (3D\u2010PSE) for the successful treatment of a primary osteosarcoma in a 7\u2010year\u2010old female Great Dane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The dog presented with a 10\u2010day history of swelling of the right distal radius. Computed tomography (CT) revealed an osteolytic lesion involving the distal metaphysis and diaphysis of the radius which was highly suspicious for an osteosarcoma (OSA). Thoracic CT showed no metastases. CT data was used to create a virtual 3D\u2010model of the affected limb within computer\u2010aided design software which was used for virtual osteotomy planning and the design of the 3D\u2010PSE. During surgery 3D\u2010printed patient\u2010specific guides were used to execute osteotomies. The 3D\u2010PSE comprised plate sections for attachment to the proximal radius and metacarpals 3, 4 and 5, and an integrated cage for bone graft to replace the radial defect. Histopathology demonstrated OSA, and postoperative adjuvant chemotherapy comprised five IV infusions of carboplatin every 3\u2009weeks. The Liverpool Osteoarthritis in Dogs (LOAD) questionnaires were completed by the owner preoperatively and for each follow\u2010up until the 6\u2010month re\u2010evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No complications occurred intra\u2010\/post\u2010 or perioperatively. LOAD scores preoperatively, and at 6, 12 and 24\u2009weeks postoperatively were 19, 13, 11 and 10. Ten months after surgery thoracic radiographs revealed multiple pulmonary metastases, but the dog remained asymptomatic for a further 6\u2009weeks when progressive dyspnea and lethargy prompted euthanasia. Lameness was absent at that time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The described novel 3D\u2010PSE provided an effective function\u2010preserving solution as part of a multimodal treatment of a giant breed dog with OSA of the distal radius.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vsu.70163","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:16:31Z","timestamp":1791976591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel 3D\u2010printed patient\u2010specific limb\u2010sparing radial endoprosthesis for treatment of primary osteosarcoma in a Great Dane"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-3851","authenticated-orcid":false,"given":"Francesca","family":"Tavola","sequence":"first","affiliation":[{"name":"Awake Veterinary Specialist Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Vet Zentrum  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Oxley","sequence":"additional","affiliation":[{"name":"Vet 3D  Staveley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Troedson","sequence":"additional","affiliation":[{"name":"Awake Veterinary Specialist Hospital  Stockholm 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