{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:32:45Z","timestamp":1698553965180},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of autologous grafts, fabricated from tissue\u2010engineered neointestine, to enhance insufficient compensation of intestinal adaptation for severe short bowel syndrome is a compelling idea. Unfortunately, current approaches and knowledge for neointestinal regeneration, unlike intestinal adaptation, are still unsatisfactory. Thus, we have designed a novel model of intestinal adaptation with simultaneous neointestinal regeneration and evaluated its feasibility for future basic research and clinical application. Fifty male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats weighing 250\u2013350\u2009g underwent this procedure and sacrificed at 4, 8, and 12 weeks postoperatively. Spatiotemporal analyses were carried out by gross, histology, and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\/protein quantification. Three rats died of operative complications. In early experiments, the use of hard silicone stent as tissue scaffold in 11 rats was unsatisfactory for neointestinal regeneration. In later experiments, when a soft silastic tube was used, the success rate increased up to 90.9%. Further analyses revealed that no neointestine developed without donor intestine; regenerated lengths of mucosa and muscle were positively related to time postsurgery but independent of donor length with 0.5 or 1\u2009cm. Other parameters of neointestinal regeneration or intestinal adaptation showed no relationship to both time postsurgery and donor length. In conclusion, this is a potentially important model for investigators searching for solutions to short bowel syndrome.<\/jats:p>","DOI":"10.1111\/wrr.12026","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T19:42:25Z","timestamp":1361907745000},"page":"309-319","source":"Crossref","is-referenced-by-count":3,"title":["A novel model for simultaneous study of neointestinal regeneration and intestinal adaptation"],"prefix":"10.1111","volume":"21","author":[{"given":"Shyh\u2010Chuan","family":"Jwo","sequence":"first","affiliation":[{"name":"Division of General Surgery Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"Institute of Bioscience and Biotechnology National Taiwan Ocean University  Keelung Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shye\u2010Jye","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Bioscience and Biotechnology National Taiwan Ocean University  Keelung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim\u2010Ray","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Chun","family":"Chiang","sequence":"additional","affiliation":[{"name":"Division of General Surgery Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Shou","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of General Surgery Chang Gung Memorial Hospital  Keelung Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan 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