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Current treatment modalities are slow acting and resource intensive. Bioengineered skin substitutes from autogenic, allogenic, or xenogenic sources have emerged as a new and alternative therapeutic option. A range of such products is licensed for clinical use, which differ in terms of structure and cellular content. Placed directly onto a prepared wound bed, skin substitutes may stimulate or accelerate healing by promoting revascularization, cellular migration, and repopulation of wound fields through provision of an appropriate scaffold material to facilitate these processes. Products containing fetal or autologous cells also benefit from early release of bioactive molecules including growth factors and cytokines. To date, limited numbers of randomized controlled trials studying skin substitutes have been published but evidence from case series and case\u2010control studies is encouraging. This review discusses chronic wound biology, the influence that skin substitutes can exert on this environment, the products currently available, and examines the evidence for their use in chronic wound management.<\/jats:p>","DOI":"10.1111\/wrr.12029","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T16:21:20Z","timestamp":1361809280000},"page":"194-210","source":"Crossref","is-referenced-by-count":112,"title":["The role of skin substitutes in the management of chronic cutaneous wounds"],"prefix":"10.1111","volume":"21","author":[{"given":"Nicholas S.","family":"Greaves","sequence":"first","affiliation":[{"name":"Plastic and Reconstructive Surgery Research Manchester Institute of Biotechnology (MIB) The University of Manchester  Manchester United Kingdom"},{"name":"University Hospital of South Manchester NHS Foundation Trust Institute of Inflammation and Repair Faculty of Medical and Human Sciences University of Manchester Manchester Academic 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