{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:52:38Z","timestamp":1783457558153,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The lectin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> has been shown to accelerate the wound\u2010healing process. The aims of this study were to evaluate the effects of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> on wound healing in the palatal mucosa of rats and to investigate the effects of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> on transforming growth factor beta (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2) and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) secretion by rat gingival fibroblasts. A surgical wound was created on the palatal mucosa of 72 rats divided into three groups according to treatment: <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2014<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrol (nontreated), <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2014<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> gel, and <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\u2014<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ehicle. Eight animals per group were sacrificed at 3, 5, and 7 days postsurgery for histology, immunohistochemistry and determination of the levels of cytokines, and growth factors. Gingival fibroblasts were incubated with 2.5\u2009\u03bcg\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> for 24, 48, and 72 hours. The expression of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 was determined by enzyme\u2010linked immunosorbent assay. Histologically, at day 7, the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> group showed earlier reepithelialization, milder inflammatory infiltration, and increased collagen fiber formation, resulting in faster maturation of granular tissue than in the other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin M\u2013induced cell proliferation in vivo and promoted a greater expression of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> in both experiments (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rtin <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> was effective in healing oral mucosa wounds in rats and was associated with increased <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> release, cell proliferation, reepithelialization, and collagen deposition and arrangement of fibers.<\/jats:p>","DOI":"10.1111\/wrr.12041","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T15:42:41Z","timestamp":1367250161000},"page":"456-463","source":"Crossref","is-referenced-by-count":28,"title":["Topical application of the lectin <scp>A<\/scp>rtin <scp>M<\/scp> accelerates wound healing in rat oral mucosa by enhancing <scp>TGF<\/scp>\u2010\u03b2 and <scp>VEGF<\/scp> production"],"prefix":"10.1111","volume":"21","author":[{"given":"Yeon J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. Estadual Paulista"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda C.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology School of Medicine of Ribeirao Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.C.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. Estadual Paulista"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro C.G.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. Estadual Paulista"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa V.B.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. Estadual Paulista"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"Spolid\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. Estadual Paulista"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Roque\u2010Barreira","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology School of Medicine of Ribeirao Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joni A.","family":"Cirelli","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery Division of Periodontology School of Dentistry UNESP\u2014Univ. 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