{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:37:52Z","timestamp":1792651072510,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T00:00:00Z","timestamp":1370908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mucosa of alimentary tract heals more rapidly than cutaneous wounds. The underlying mechanisms of this enhanced healing have not been completely elucidated. Constant exposure to salivary growth factors has been shown to play a critical role in mucosal homeostasis and tissue repair. Angiogenesis also has an essential role in successful wound repair. One of the main angiogenic growth factors, vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>), has a pleiotropic role in tissue repair via neovascularization, reepithelialization, and regulation of extracellular matrix. We have previously reported a critical role for salivary <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> in bowel adaptation after small bowel resection. We hypothesize that salivary <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> is an essential stimulus for oral mucosal tissue repair, and use the murine palatal wound model to test our hypothesis. In a loss\u2010of\u2010function experiment, we removed the primary source of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> production through selective submandibular gland (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>) sialoadenectomy in a murine model and observed the effects on wound closure and neovascularization. We then performed a selective loss\u2010of\u2010function experiment using the protein <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010Trap to inhibit salivary <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>. In a gain\u2010of\u2010function experiment, we supplemented oral <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> sialoadenectomy. After <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> sialoadenectomy, there was significant reduction in salivary <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> level, wound closure, and vessel density. Lower levels of salivary <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> were correlated with impaired neovascularization and reepithelialization. The selective blockade of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> using <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010Trap resulted in a similar impairment in wound healing and neovascularization. The sole supplementation of oral <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> sialoadenectomy rescued the impaired wound healing phenotype and restored neovascularization to normal levels. These data show a novel role for salivary\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> in mucosal wound healing, and provide a basis for the development of novel therapeutics aimed at augmenting wound repair of the oral mucosa, as well as wounds at other sites in the alimentary tract.<\/jats:p>","DOI":"10.1111\/wrr.12065","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T14:47:55Z","timestamp":1370962075000},"page":"554-562","source":"Crossref","is-referenced-by-count":61,"title":["Role of salivary vascular endothelial growth factor (<scp>VEGF<\/scp>) in palatal mucosal wound healing"],"prefix":"10.1111","volume":"21","author":[{"given":"Sundeep G.","family":"Keswani","sequence":"first","affiliation":[{"name":"Center for Molecular Fetal Therapy Division of Pediatric General, Thoracic, and Fetal Surgery Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine  Cincinnati 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