{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:14:32Z","timestamp":1791555272531,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cold atmospheric plasma has already been shown to decrease the bacterial load in chronic wounds. However, until now it is not yet known if plasma treatment can also improve wound healing. We aimed to assess the impact of cold atmospheric argon plasma on the process of donor site healing. Forty patients with skin graft donor sites on the upper leg were enrolled in our study. The wound sites were divided into two equally sized areas that were randomly assigned to receive either plasma treatment or placebo (argon gas) for 2 minutes. Donor site healing was evaluated independently by two blinded dermatologists, who compared the wound areas with regard to reepithelialization, blood crusts, fibrin layers, and wound surroundings. From the second treatment day onwards, donor site wound areas treated with plasma (<jats:italic>n<\/jats:italic>\u2009=\u200934) showed significantly improved healing compared with placebo\u2010treated areas (day 1, <jats:italic>p<\/jats:italic>\u2009=\u20090.25; day 2, <jats:italic>p<\/jats:italic>\u2009=\u20090.011; day 3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; day 4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; day 5, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; day 6, <jats:italic>p<\/jats:italic>\u2009=\u20090.008; day 7, <jats:italic>p<\/jats:italic>\u2009=\u20090.031). Positive effects were observed in terms of improved reepithelialization and fewer fibrin layers and blood crusts, whereas wound surroundings were always normal, independent of the type of treatment. Wound infection did not occur in any of the patients, and no relevant side effects were observed. Both types of treatment were well tolerated. The mechanisms contributing to these clinically observed effects should be further investigated.<\/jats:p>","DOI":"10.1111\/wrr.12078","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T15:03:24Z","timestamp":1376319804000},"page":"800-807","source":"Crossref","is-referenced-by-count":147,"title":["Randomized placebo\u2010controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites"],"prefix":"10.1111","volume":"21","author":[{"given":"Julia","family":"Heinlin","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Extraterrestrial Physics  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Zeman","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Bunk","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Extraterrestrial Physics  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Isbary","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Munich\u2010Schwabing  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Landthaler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Maisch","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Monetti","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Extraterrestrial Physics  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Morfill","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Extraterrestrial Physics  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Extraterrestrial Physics  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Steinbauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Stolz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Munich\u2010Schwabing  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Karrer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.200700154"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/11\/11\/115012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03702.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/11\/11\/115013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04395.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09744.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10923.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07495_supp.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.020263-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0387-2"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"A prospective trial comparing Biobrane, Duoderm and xeroform for skin graft donor sites","volume":"173","author":"Feldman DL","year":"1991","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_8_13_1","volume-title":"Nonparametric analysis of longitudinal data in factorial experiments","author":"Brunner E","year":"2001"},{"key":"e_1_2_8_14_1","unstructured":"DaeschleinG DarmK MajunkeS KindelE WeltmannKD JuengerM.In vivo monitoring of atmospheric pressure plasma jet (APPJ) skin therapy by confocal laserscan microscopy (CLSM). Paper presented at the Second International Conference on Plasma Medicine San Antonio TX 2009."},{"key":"e_1_2_8_15_1","unstructured":"WendeK LandsbergK LindequistU WeltmannKD v.WoedtkeT.Microorganisms human cells and cold atmospheric plasma \u2010 looking for an intersection. Paper presented at the 2nd International Workshop on Plasma\u2013Tissue Interactions Greifswald Germany 2009."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/TPS.2004.833401"},{"key":"e_1_2_8_17_1","unstructured":"PomplR ShimizuT SchmidtHU BunkW JamitzkyF SteffesB et\u2009al.Efficiency and medical compatibility of low\u2010temperature plasma sterilization. Paper presented at the 6th International Conference on Reactive Plasmas Matsushima Japan 2006."},{"key":"e_1_2_8_18_1","unstructured":"FetykovAI AvdeevaEA FultonJ FerrelJ GotsevVA GalovAA.The effectiveness of cold plasma treatment of diabetic feet syndrome complicated by purulonecrotic process. Paper presented at the Second International Conference on Plasma Medicine San Antonio TX 2009."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02446923"},{"key":"e_1_2_8_20_1","first-page":"43","article-title":"[NO\u2010therapy in the treatment of purulent and necrotic lesions of lower extremities in diabetic patients]","volume":"12","author":"Shulutko AM","year":"2004","journal-title":"Khirurgiia (Mosk)"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2005.03.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01195.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3020223"},{"key":"e_1_2_8_24_1","first-page":"3578","article-title":"Non\u2010thermal dielectric barrier discharge plasma treatment of endothelial cells","volume":"2008","author":"Kalghatgi SU","year":"2008","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_2_8_25_1","unstructured":"TipaRS Adamowicz\u2010StoffelsE KroesenGMW.The effects of cold plasma in wound healing. Paper presented at the Second International Conference on Plasma Medicine San Antonio TX 2009."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9868-x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2011.0220"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26252"},{"issue":"2","key":"e_1_2_8_29_1","first-page":"154","article-title":"[Non thermal plasmas, a new strategy in oncology?]","volume":"28","author":"Fridman G","year":"2012","journal-title":"Medecine s\\Sciences: M\/S"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2010.10.003"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12078","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:40:37Z","timestamp":1696149637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/wrr.12078"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12078","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,12]]}}}