{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:38:11Z","timestamp":1788781091735,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic ulcers ((arterio)venous, decubitus, or postoperative) have no tendency to heal within a period of at least 3 months despite optimal therapy according to internationally accepted guidelines. This retrospective study evaluates the safety and efficacy of an autologous, dermal\u2010epidermal skin substitute (SS) for treating ulcers of various origins. Ulcers were treated within 7 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>utch centers over 5 years. Sixty\u2010six ulcers (size: 0.75\u2013150\u2009cm<jats:sup>2<\/jats:sup>; duration: 0.25\u201332 years) with a follow\u2010up time of 24 weeks after a single\u2010skin substitute application were assessed. Wound\u2010bed preparation consisted of vacuum\u2010assisted\u2010closure\u2010therapy (5 days, hospitalized) or application of acellular dermis (5\u20137 days, outpatient). Time to heal, adverse events, and recurrence 1 year after complete healing were recorded. Complete ulcer healing occurred in 36 of 66 ulcers (55%) at 24 weeks. At that time point, a further 29% of ulcers showed decrease in ulcer size between 50 and 99%. No difference was observed between the hospitalized vs. outpatient treatment with complete healing. There were 32 of 36 healed ulcers that were available for follow\u2010up 1 year after complete closure, of which 27 (84%) were still closed. Only two minor\/moderate possibly related adverse events were recorded. This retrospective analysis shows that SS provides a safe and successful treatment for particularly chronic ulcers of various origins.<\/jats:p>","DOI":"10.1111\/wrr.12082","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T15:40:10Z","timestamp":1375976410000},"page":"667-676","source":"Crossref","is-referenced-by-count":24,"title":["Autologous skin substitute for hard\u2010to\u2010heal ulcers: Retrospective analysis on safety, applicability, and efficacy in an outpatient and hospitalized setting"],"prefix":"10.1111","volume":"21","author":[{"given":"Chantal S.","family":"Blok","sequence":"first","affiliation":[{"name":"Department of Dermatology VU Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselot","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith M.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"van Montfrans","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk M.","family":"van den Hoogenband","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Mooij","sequence":"additional","affiliation":[{"name":"Centrum Oosterwal  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A.","family":"Gauw","sequence":"additional","affiliation":[{"name":"Centrum Oosterwal  Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A. 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