{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:56:30Z","timestamp":1791510990090,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The exact mechanism for the occurrence of sickle leg ulcers (<jats:styled-content style=\"fixed-case\">SLUs<\/jats:styled-content>) has not been fully explained, although, popular opinion supports a multifactorial etio\u2010pathogenetic process. Leg ulceration in sickle cell is a chronic and debilitating condition which is difficult to treat and may worsen the psychosocial impact of this illness. This study aims to evaluate the laboratory and clinical correlates of <jats:styled-content style=\"fixed-case\">SLUs<\/jats:styled-content>. One hundred sixty\u2010seven patients who had been diagnosed with sickle cell anemia (homozygous <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>) had their steady\u2010state hemoglobin concentration (Hb), hematocrit, white cell count, platelet count, serum bilirubin, and aspartate transaminase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>) as well as frequency of crisis per annum evaluated with respect to their relationship to the occurrence of leg ulcers. They were aged 6\u201353 years (mean age 24.3 years), and prevalence of leg ulcer was found to be 2.75 per 1000 (2.54 per 1000 in females and 2.83 per 1000 in males). The independent sample <jats:italic>t<\/jats:italic>\u2010test showed a significant difference in the serum <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> levels in those with <jats:styled-content style=\"fixed-case\">SLU<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u2009=\u20090.029), though a positive correlation did not exist. Other predictors of disease severity found to have positive relationship with each other were the <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> and total serum bilirubin 0.207 (<jats:italic>p<\/jats:italic>\u2009=\u20090.012); Hb and age 0.130 (<jats:italic>p<\/jats:italic>\u2009=\u20090.035); Hb and white cell count \u22120.159 (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), white cell count and age \u22120.113 (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). <jats:styled-content style=\"fixed-case\">SLUs<\/jats:styled-content> do not occur in patients with severe disease in sickle cell. The clinical and laboratory indicators of severe sickle cell disease do not correlate positively with the occurrence of <jats:styled-content style=\"fixed-case\">SLU<\/jats:styled-content>. Serum <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> may have a relationship with leg ulceration in these patients. Environmental factors most likely play a major part in the etiopathogenesis of leg ulcer and this may require further studies in different sociocultural settings.<\/jats:p>","DOI":"10.1111\/wrr.12100","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T14:44:48Z","timestamp":1382021088000},"page":"808-812","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of clinical and laboratory correlates of sickle leg ulcers"],"prefix":"10.1111","volume":"21","author":[{"given":"Anazoeze Jude","family":"Madu","sequence":"first","affiliation":[{"name":"Department of Haematology &amp; Immunology University of Nigeria Enugu Campus  Enugu Nigeria"},{"name":"Department of Haematology &amp; Immunology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agozie","family":"Ubesie","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Nigeria Enugu Campus  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenechi Anthony","family":"Madu","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery National Orthopaedic Hospital  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bismarck","family":"Okwor","sequence":"additional","affiliation":[{"name":"Burns and Plastic Surgery National Orthopaedic Hospital  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwudi","family":"Anigbo","sequence":"additional","affiliation":[{"name":"Department of Haematology &amp; Immunology University of Nigeria Teaching Hospital  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"179","article-title":"Peculiar elongated and sickle\u2010shaped red blood corpuscles in a case of severe anemia. 1910","volume":"74","author":"Herrick JB","year":"2001","journal-title":"Yale J Biol Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988398.ch3"},{"key":"e_1_2_6_5_1","first-page":"492","article-title":"Pathophysiology and treatment of sickle cell disease","volume":"3","author":"Raphael RI","year":"2005","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.01.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920153"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21838"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07115.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002095"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000405216.27050.97"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2003.8.2.11091"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000419408.37323.0c"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(03)00037-7"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:40:06Z","timestamp":1696149606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/wrr.12100"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12100","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}