{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:09:38Z","timestamp":1789477778287,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence and costs of chronic venous ulcer care in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> are increasing. The <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ohns <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>opkins <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vidence\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ased <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ractice <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter recently completed a systematic review of the comparative effectiveness of advanced wound dressings, antibiotics, and surgical management of chronic venous ulcers. Of 10,066 citations identified in the literature search, only 66 (0.06%) met our liberal inclusion criteria for providing evidence on the effectiveness of interventions for chronic venous ulcers. Based on review of those studies, members of our team and a panel of informed stakeholders identified important research gaps and methodological deficiencies and prioritized specific future research needs. Based on that review, we provide the results of our assessment of future research needs for chronic venous ulcer care. Advanced wound dressings were considered to have the highest priority for future research, followed by venous surgery and antibiotics. An imperative from our assessment is that future research evaluating interventions for chronic venous ulcers meet quality standards. In a time of increasing cost pressure, the wound care community needs to develop high\u2010quality evidence to justify the use of present and future therapeutic modalities.<\/jats:p>","DOI":"10.1111\/wrr.12102","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T14:44:50Z","timestamp":1382021090000},"page":"34-42","source":"Crossref","is-referenced-by-count":59,"title":["Chronic venous leg ulcer treatment: Future research needs"],"prefix":"10.1111","volume":"22","author":[{"given":"Gerald","family":"Lazarus","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fran","family":"Valle","sequence":"additional","affiliation":[{"name":"School of Nursing University of Maryland  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Malas","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Qazi","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa M.","family":"Maruthur","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Doggett","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwakemi A.","family":"Fawole","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Bass","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Zenilman","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Medicine and Surgery School of Medicine Johns Hopkins University  Queenstown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0802444"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6045"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.102"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.26.1.38"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055289"},{"key":"e_1_2_4_9_1","unstructured":"SonnadS GoldsackJ MohrP WhicherD.Methodological recommendations for comparative effectiveness research on the treatment of chronic wounds. Version 2: final. Center for Medical Technology Policy.2012. Available athttp:\/\/www.cmtpnet.org\/effectiveness\u2010guidance\u2010documents\/negative\u2010pressure\u2010wound\u2010therapy\u2010egd\/(accessed October 31 2012)."},{"key":"e_1_2_4_10_1","volume-title":"Chronic venous ulcers: a comparative effectiveness review of treatment modalities","author":"Zenilman J"},{"key":"e_1_2_4_11_1","volume-title":"Chronic venous leg ulcer treatment: future research needs","author":"Lazarus G"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.008"},{"key":"e_1_2_4_13_1","volume-title":"Framework for considering study designs for future research needs","author":"Carey TS","year":"2012"},{"key":"e_1_2_4_14_1","volume-title":"Defining an optimal format for presenting research needs","author":"Trikalinos TA","year":"2011"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:37:48Z","timestamp":1695980268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/wrr.12102"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12102","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}