{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:00:48Z","timestamp":1791889248426,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    It has been known for centuries that the application of larvae is useful to heal certain wounds by facilitating debridement of necrotic tissue,\n                    <jats:sup>1<\/jats:sup>\n                    yet the efficacy of larval therapy continues to be debatable. This study compared the clinical effectiveness of a larval therapy dressing (\n                    <jats:styled-content style=\"fixed-case\">BioFOAM<\/jats:styled-content>\n                    ) with a standard debridement technique (Purilon gel; hydrogel) in terms of time to debridement of venous (\n                    <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>\n                    ) or mixed arterial\/venous (\n                    <jats:styled-content style=\"fixed-case\">MLU<\/jats:styled-content>\n                    ) leg ulcers. Data analyses were conducted on 88 subjects. Sixty\u2010four subjects completed the full study. Of these, 31 of the 32 (96.9%) patients who completed treatment in the larvae arm debrided fully, compared with 11 of the 32 (34.4%) patients who completed the hydrogel arm. In addition, 42 (48%) ulcers fully debrided within the 21\u2010day intervention phase, 31 (67.4%) from the larvae arm (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200946), and 11 (26.2%) from the hydrogel arm (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200942), which was statistically significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) in support of larvae. A statistically significant difference was also observed between treatment arms with regard to numbers of dressing changes during the intervention phase of the study (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in that subjects in the larvae arm required significantly fewer dressing changes(mean\u2009=\u20092.83) than those in the hydrogel arm (mean\u2009=\u20095.40). There were no statistically significant differences in the clinical condition of the wound bed and surrounding skin by intervention. Subjects in the larvae arm experienced more ulcer\u2010related pain or discomfort than subjects in the hydrogel arm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). This study provided good evidence to show that larval therapy, in the form of a\n                    <jats:styled-content style=\"fixed-case\">BioFOAM<\/jats:styled-content>\n                    dressing, debrided\n                    <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">MLU<\/jats:styled-content>\n                    considerably more quickly than a hydrogel, although the possibility of resloughing should be closely monitored.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12127","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T11:36:16Z","timestamp":1385984176000},"page":"43-51","source":"Crossref","is-referenced-by-count":73,"title":["A randomized controlled trial of larval therapy for the debridement of leg ulcers: Results of a multicenter, randomized, controlled, open, observer blind, parallel group study"],"prefix":"10.1111","volume":"22","author":[{"given":"Elizabeth","family":"Mudge","sequence":"first","affiliation":[{"name":"Wound Healing Research Unit Cardiff University School of Medicine  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Price","sequence":"additional","affiliation":[{"name":"Student Experience and Academic Standards Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walkley","family":"Neal","sequence":"additional","affiliation":[{"name":"Wound Healing Research Unit Cardiff University School of Medicine  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith G.","family":"Harding","sequence":"additional","affiliation":[{"name":"Wound Healing Research Unit Cardiff University School of Medicine  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-157-02-01"},{"key":"e_1_2_6_3_1","volume-title":"Skin breakdown: the silent epidemic","author":"Posnett J","year":"2007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00337.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2003.00859.x"},{"key":"e_1_2_6_6_1","first-page":"70","article-title":"Critical colonisation of chronic wounds: microbial mechanisms","volume":"4","author":"White R","year":"2008","journal-title":"Wounds UK"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00303.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00321.x"},{"key":"e_1_2_6_9_1","first-page":"108","article-title":"Surgical site infections: biofilms, dehiscence and delayed healing","volume":"4","author":"Wolcott R","year":"2008","journal-title":"Wounds UK"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm407"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00625.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"CowenLJ StechmillerJK PhillipsP YangQ SchultzG.Chronic wounds biofilms and use of medicinal larvae. Ulcers Article ID 487024 7 pages 2013.","DOI":"10.1155\/2013\/487024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2012.01029.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1999.8.5.25872"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1999.8.6.25888"},{"key":"e_1_2_6_16_1","unstructured":"LeaperD.Sharp technique for wound debridement.2002. Available athttp:\/\/www.worldwidewounds.com\/2002\/december\/Leaper\/Sharp\u2010Debridement.html(accessed November 1 2013)."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.Sup1.S1"},{"issue":"1","key":"e_1_2_6_18_1","first-page":"17","article-title":"The debridement of chronic wounds: a systematic review","volume":"3","author":"Bradley M","year":"1999","journal-title":"Health Technol Assess"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta5140"},{"key":"e_1_2_6_20_1","first-page":"777","volume-title":"ABC of wound healing","author":"Jones V","year":"2006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-206X(00)80036-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.12968\/jowc.1998.7.10.521","article-title":"The use of larval therapy in wound management","volume":"7","author":"Thomas S","year":"1998","journal-title":"J Wound Care"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0251458"},{"key":"e_1_2_6_24_1","first-page":"835","article-title":"Proteolytic activity of blowfly larvae secretions in experimental burns","volume":"90","author":"Vistnes LM","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310016689"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09854.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.1516"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130410.x"},{"key":"e_1_2_6_29_1","first-page":"18","article-title":"Maggot therapy for wound healing: clinical relevance, mechanisms of action and future prospects","volume":"5","author":"Cazander G","year":"2009","journal-title":"J Wound Technol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1309-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13550"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121739"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2340\/00015555-0433","article-title":"Leg ulcer point prevalence can be decreased by a broad\u2010scale intervention: a follow\u2010up cross sectional study of a defined geographical population","volume":"88","author":"Forssgren A","year":"2008","journal-title":"Acta Derm Venerol"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:38:12Z","timestamp":1695965892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/wrr.12127"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12127","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,2]]}}}