{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:13:36Z","timestamp":1791893616097,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability of the anterior cruciate ligament (<jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>) to heal after injury declines within the first 2 weeks after <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> rupture. To begin to explore the mechanism behind this finding, we quantified the expression of genes for collagen <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, decorin, tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, and alpha smooth muscle actin, as well as matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20101 and \u201013 gene expression within multiple tissues of the knee joint after <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> injury in a large animal model over a 2\u2010week postinjury period. Gene expression of collagen <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, decorin, and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101 was highest in the synovium, whereas the highest <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013 gene expression levels were found in the <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>. The gene expression for collagen and decorin increased over the 2 weeks to levels approaching that in the ligament and synovium; however, no significant increase in either of the <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s was found in the provisional scaffold. This suggests that although the <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> and synovium up\u2010regulate both anabolic and catabolic factors, the provisional scaffold is primarily anabolic in function. The relative lack of provisional scaffold formation within the joint environment may thus be one of the key reasons for <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> degradation after injury.<\/jats:p>","DOI":"10.1111\/wrr.12130","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T15:59:26Z","timestamp":1389023966000},"page":"103-110","source":"Crossref","is-referenced-by-count":26,"title":["Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury"],"prefix":"10.1111","volume":"22","author":[{"given":"Carla M.","family":"Haslauer","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Boston Children's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt L.","family":"Proffen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Boston Children's Hospital  Boston 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