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In this study, we present a novel imaging method that provides reproducible, sensitive, and unbiased assessments of postsurgical scarring. We used this approach to investigate the possibility that genetic variants in orofacial clefting genes are associated with suboptimal healing. Red\u2010green\u2010blue digital images of postsurgical scars of 68 patients, following unilateral cleft lip repair, were captured using the <jats:styled-content style=\"fixed-case\">3dMD<\/jats:styled-content> imaging system. Morphometric and colorimetric data of repaired regions of the philtrum and upper lip were acquired using ImageJ software, and the unaffected contralateral regions were used as patient\u2010specific controls. Repeatability of the method was high with intraclass correlation coefficient score &gt;\u20090.8. This method detected a very significant difference in all three colors, and for all patients, between the scarred and the contralateral unaffected philtrum (<jats:italic>p<\/jats:italic> ranging from 1.20<jats:sup>\u221205<\/jats:sup> to 1.95<jats:sup>\u221214<\/jats:sup>). Physicians\u2019 clinical outcome ratings from the same images showed high interobserver variability (overall <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>earson coefficient\u2009=\u20090.49) as well as low correlation with digital image analysis results. Finally, we identified genetic variants in <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content><jats:styled-content style=\"fixed-case\">GFB3<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ARHGAP29<\/jats:styled-content><\/jats:italic> associated with suboptimal healing outcome.<\/jats:p>","DOI":"10.1111\/wrr.12141","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T16:09:03Z","timestamp":1395072543000},"page":"228-238","source":"Crossref","is-referenced-by-count":9,"title":["Digital imaging analysis to assess scar phenotype"],"prefix":"10.1111","volume":"22","author":[{"given":"Brian J.","family":"Smith","sequence":"first","affiliation":[{"name":"College of Dentistry The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichole","family":"Nidey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven F.","family":"Miller","sequence":"additional","affiliation":[{"name":"Dows Institute for Dental Research The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina M.","family":"Moreno Uribe","sequence":"additional","affiliation":[{"name":"Dows Institute for Dental Research The University of Iowa  Iowa City Iowa"},{"name":"Department of Orthodontics College of Dentistry The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian L.","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Grant S.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Wehby","sequence":"additional","affiliation":[{"name":"Department of Health and Management Policy College of Public Health The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Dunnwald","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00042728-200506000-00011","article-title":"Normal cutaneous wound healing: clinical correlations with cellular and molecular events","volume":"31","author":"Baum CL","year":"2005","journal-title":"Dermatol 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