{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:20:01Z","timestamp":1773012001492,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000849","name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["G0800696"],"award-info":[{"award-number":["G0800696"]}],"id":[{"id":"10.13039\/501100000849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000885","name":"Dr Hadwen Trust for Humane Research","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100000885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000690","name":"Research Councils UK","doi-asserted-by":"publisher","award":["G0800696"],"award-info":[{"award-number":["G0800696"]}],"id":[{"id":"10.13039\/501100000690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a spectrum\/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring within skin and the nonhealing of chronic skin wounds. Central to these outcomes is the role of the fibroblast. Global gene expression profiling utilizing microarrays is starting to give insight into the role of such cells during the healing process, but no studies to date have produced a gene signature for this wound healing continuum. Microarray analysis of adult oral mucosal fibroblast (<jats:styled-content style=\"fixed-case\">OMF<\/jats:styled-content>), normal skin fibroblast (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>), and chronic wound fibroblast (<jats:styled-content style=\"fixed-case\">CWF<\/jats:styled-content>) at 0 and 6 hours post\u2010serum stimulation was performed. Genes whose expression increases following serum exposure in the order <jats:styled-content style=\"fixed-case\">OMF<\/jats:styled-content>\u2009&lt;\u2009<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2009&lt;\u2009<jats:styled-content style=\"fixed-case\">CWF<\/jats:styled-content> are candidates for a negative\/impaired healing phenotype (the dysfunctional healing group), whereas genes with the converse pattern are potentially associated with a positive\/preferential healing phenotype (the enhanced healing group). Sixty\u2010six genes in the enhanced healing group and 38 genes in the dysfunctional healing group were identified. Overrepresentation analysis revealed pathways directly and indirectly associated with wound healing and aging and additional categories associated with differentiation, development, and morphogenesis. Knowledge of this wound healing continuum gene signature may in turn assist in the therapeutic assessment\/treatment of a patient's wounds.<\/jats:p>","DOI":"10.1111\/wrr.12170","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T22:40:16Z","timestamp":1400625616000},"page":"399-405","source":"Crossref","is-referenced-by-count":32,"title":["Identification of a transcriptional signature for the wound healing continuum"],"prefix":"10.1111","volume":"22","author":[{"given":"Matthew A.","family":"Peake","sequence":"first","affiliation":[{"name":"Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Caley","sequence":"additional","affiliation":[{"name":"Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Giles","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genetics School of Medicine, Cardiff University  Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Wall","sequence":"additional","affiliation":[{"name":"Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry School of Dentistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Enoch","sequence":"additional","affiliation":[{"name":"Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Tissue Engineering and Reparative Dentistry School of Dentistry"},{"name":"Wound Healing Research Unit School of Medicine, Cardiff University  Cardiff Wales United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay 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