{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:43:48Z","timestamp":1775594628116,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibroproliferative processes are regulated by a wide variety of tissue components and genetic factors. However, whether there are genetic differences in peritoneal fibroproliferative tissue formation, with consequent differences in response to drug treatment, is unclear. We characterize the influence of the genetic background on peritoneal fibroproliferative tissue induced by sponge implants in <jats:styled-content style=\"fixed-case\">DBA\/1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">Swiss<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/6, and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ALB\/c mouse strains. In addition, responses to dipyridamole in the implants were evaluated. Angiogenesis, assessed by intra\u2010implant hemoglobin content, was highest in Swiss mice, whereas levels of vascular endothelial growth factor were highest in <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/6 mice. The levels of pro\u2010inflammatory cytokines and of inflammatory enzymes (myeloperoxidase\u2010 and <jats:styled-content style=\"fixed-case\"><jats:italic>N<\/jats:italic><\/jats:styled-content>\u2010acetyl\u2010\u03b2\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\u2010glucosaminidase) were also strain\u2010related. The pro\u2010fibrogenic markers transforming growth factor beta\u20101 and collagen were lowest in implants placed in <jats:styled-content style=\"fixed-case\">DBA\/1<\/jats:styled-content> mice, whereas those in <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/6 mice had the highest levels. Differential sensitivity to dipyridamole was also observed, with this compound being pro\u2010angiogenic in implants placed in <jats:styled-content style=\"fixed-case\">DBA\/1<\/jats:styled-content> mice but antiangiogenic in implants placed in <jats:styled-content style=\"fixed-case\">Swiss<\/jats:styled-content>. An overall anti\u2010inflammatory response was observed in the inbred strains. Antifibrogenic effects were observed only in implants placed in <jats:styled-content style=\"fixed-case\">C57BL<\/jats:styled-content>\/6 mice. These important strain\u2010related differences in the development of peritoneal fibrosis and in response to dipyridamole must be considered in the design and analysis of studies on fibrogenesis in mice.<\/jats:p>","DOI":"10.1111\/wrr.12177","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T22:40:16Z","timestamp":1400625616000},"page":"381-389","source":"Crossref","is-referenced-by-count":10,"title":["Genetic strain differences in the development of peritoneal fibroproliferative processes in mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Suzane M.","family":"Marques","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pollyana R.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula P.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of General Pathology Institute of Biological Sciences Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso T. R.","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.","family":"Parreiras","sequence":"additional","affiliation":[{"name":"Ren\u00e9 Rachou Research Center  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica A. N.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of General Pathology Institute of Biological Sciences Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia P.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5390"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.09.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.27.2.4674"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00272.2012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31487"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.871"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00047.2007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.08.011"},{"key":"e_1_2_6_11_1","first-page":"60","article-title":"Intestinal obstruction from adhesions\u2014how big is the problem?","volume":"72","author":"Menzies D","year":"1990","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2741\/chegini"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.556"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130402.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0747-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33083"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00357.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs289"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30810"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2009.08.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2012.012066"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.08.134"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00749.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705143162005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00712-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000044907"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00381.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.6.1425"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00909.2006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.909"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.01.005"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054526359"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.12.010"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.08.008"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/91f1d7f8-b09d-4067-943c-148e926b403b"},{"issue":"2","key":"e_1_2_6_38_1","first-page":"35S","article-title":"Platelet rich plasma therapy: inflammatory molecules involved in tissue healing","volume":"26","author":"Galliera E","year":"2012","journal-title":"J Biol Regul Homeost Agents"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:04:14Z","timestamp":1695992654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/wrr.12177"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12177","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}