{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:01:56Z","timestamp":1776272516571,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limitation of ankle movement may contribute to calf muscle pump failure, which is thought to contribute to venous leg ulcer formation, which affects nearly 1 million <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>mericans. We therefore wished to study ankle movement in patients with venous leg ulcers and its effect on healing. Using goniometry, we measured baseline ankle range of motion in venous leg ulcer patients from a Phase 2 dose\u2010finding study of an allogeneic living cell bioformulation. Two hundred twenty\u2010seven patients were enrolled in four active treatment groups and one standard\u2010care control group, all receiving compression therapy. Goniometry data from a control group of 49 patients without venous disease, from a previous study, was used for comparison. We found patients with active venous leg ulcers had significantly reduced ankle range of motion compared with the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). After 12\u2009weeks of therapy, baseline ankle range of motion was not associated with healing, as there was no significant difference between healed and nonhealed groups, suggesting that ankle range of motion is not important in venous leg ulcer healing or, more likely, is overcome by compression. However, patients with venous ulcers located on the leg (as opposed to the ankle) had significantly higher ankle range of motion for plantar flexion and inversion (<jats:italic>p<\/jats:italic>\u2009=\u20090.021 and <jats:italic>p<\/jats:italic>\u2009=\u20090.034, respectively) and improved healing with both cell bioformulation and standard care (<jats:italic>p<\/jats:italic>\u2009=\u20090.011), suggesting that wound location is an important variable for ankle range of motion as well as for healing outcomes.<\/jats:p>","DOI":"10.1111\/wrr.12186","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T21:17:56Z","timestamp":1405718276000},"page":"492-496","source":"Crossref","is-referenced-by-count":17,"title":["The effect of ankle range of motion on venous ulcer healing rates"],"prefix":"10.1111","volume":"22","author":[{"given":"Elizabeth","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Baquerizo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freya","family":"Van Driessche","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert B.","family":"Slade","sequence":"additional","affiliation":[{"name":"Smith &amp; Nephew  Fort Worth Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pieper","sequence":"additional","affiliation":[{"name":"College of Nursing Wayne State University  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Kirsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/319360"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.00993.x"},{"key":"e_1_2_7_4_1","first-page":"38","article-title":"Venous ulcers: pathophysiology and treatment options","volume":"51","author":"Trent JT","year":"2005","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70030-7"},{"key":"e_1_2_7_6_1","first-page":"109","article-title":"[Arthrogenic congestive syndrome]","volume":"12","author":"Hach W","year":"1983","journal-title":"VASA"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980080203"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1885"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2007.007039"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/026835550101600110","article-title":"Ankle motility is a risk factor for helaing of chronic venous leg ulcers","volume":"16","author":"Barwell JR","year":"2001","journal-title":"Phlebology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60644-8"},{"key":"e_1_2_7_13_1","first-page":"95","article-title":"Parameter for measurement of wound closure","volume":"3","author":"Gillman TH","year":"1990","journal-title":"Wounds"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6723"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1547-5069.2007.00186.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00468.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.38.2.171"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051026"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.12.055"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.09.036"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00995.x"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:07:12Z","timestamp":1696176432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/wrr.12186"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12186","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}