{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:28:22Z","timestamp":1791293302861,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pathological scars, namely, keloids and hypertrophic scars (<jats:styled-content style=\"fixed-case\">HSs<\/jats:styled-content>), are caused by excessive cutaneous wound healing that is characterized by histological extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) accumulation, clinically relevant irritating symptoms, and frequent recurrence after surgical excision. To date, there are few effective and specific treatments. This partly reflects the poor understanding of the etiology of these scars and the lack of a suitable animal model. Systemic hypertension has been suggested to participate in pathological scarring. The evidence that supports this hypothesis is reviewed here. Thus, hypertension associates with changes that resemble the aberrant cutaneous wound\u2010healing phases that characterize pathological scar development. It also associates with profibrotic functional changes in the cells that constitute keloids and <jats:styled-content style=\"fixed-case\">HSs<\/jats:styled-content> (endothelial cells, pericytes\/myofibroblasts, dermal fibroblasts, and mast cells) and profibrotic <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> remodeling. These hypertension\u2010associated changes are mediated to some extent by inflammation, hypoxia, and the angiotensin\/renin\u2010angiotensin\u2010aldosterone system. Thus, hypertension may be an aggravating\/risk factor for keloids and <jats:styled-content style=\"fixed-case\">HSs<\/jats:styled-content>. This will help to identify patients who are prone to heavy scars after surgery or postsurgical recurrence. Moreover, pharmacological agents for the prophylaxis and treatment of hypertension\u2010induced fibrosis in other organs may also be useful for keloids\/<jats:styled-content style=\"fixed-case\">HSs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/wrr.12197","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T08:18:48Z","timestamp":1401956328000},"page":"462-466","source":"Crossref","is-referenced-by-count":62,"title":["The link between hypertension and pathological scarring: Does hypertension cause or promote keloid and hypertrophic scar pathogenesis?"],"prefix":"10.1111","volume":"22","author":[{"given":"Chenyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery Nippon Medical School  Tokyo Japan"},{"name":"Department of Plastic Surgery Meitan General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01118.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0b013e31829c4597"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2000.0207"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70568-X"},{"key":"e_1_2_7_6_1","first-page":"e25","article-title":"CASE REPORT Total management of a severe case of systemic keloids associated with high blood pressure (hypertension): clinical symptoms of keloids may be aggravated by hypertension","volume":"13","author":"Ogawa R","year":"2013","journal-title":"Eplasty"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a97f9e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819a34db"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051812"},{"key":"e_1_2_7_10_1","first-page":"1","article-title":"Hypertension among adults in the United States, 2009\u20132010","volume":"107","author":"Yoon SS","year":"2012","journal-title":"NCHS Data Brief"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150466"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000340033"},{"key":"e_1_2_7_13_1","first-page":"17","article-title":"A comparison of the microvascular response in the healing wound in the spontaneously hypertensive and non\u2010hypertensive rat","volume":"2","author":"Rendell MS","year":"2000","journal-title":"Int J Surg Investig"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910283"},{"key":"e_1_2_7_15_1","first-page":"3810","article-title":"Hypoxia promotes fibrogenesis in vivo via HIF\u20101 stimulation of epithelial\u2010to\u2010mesenchymal transition","volume":"117","author":"Higgins DF","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00007.2009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018040-00002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.11.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91047-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282efeecb"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80078-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2022"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.08.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.147843"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700564"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00374.2007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.123158"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148709069596"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5385-4_4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01438.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.535"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:06:56Z","timestamp":1696176416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/wrr.12197"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12197","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}