{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:27Z","timestamp":1792798227835,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yangtze River Scholar Award Program"},{"name":"National Science Fund","award":["81101825"],"award-info":[{"award-number":["81101825"]}]},{"name":"National Science Fund","award":["81272424"],"award-info":[{"award-number":["81272424"]}]},{"name":"National Science Fund","award":["81172294"],"award-info":[{"award-number":["81172294"]}]},{"DOI":"10.13039\/501100013286","name":"Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20100142120033"],"award-info":[{"award-number":["20100142120033"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013286","name":"Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20120142110072"],"award-info":[{"award-number":["20120142110072"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003172","name":"HUST","doi-asserted-by":"crossref","award":["2011JC080"],"award-info":[{"award-number":["2011JC080"]}],"id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003172","name":"HUST","doi-asserted-by":"crossref","award":["2014QN039"],"award-info":[{"award-number":["2014QN039"]}],"id":[{"id":"10.13039\/501100003172","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Graduates' Innovation Fund of Huazhong University of Science & Technology","award":["HF-11-31-2013"],"award-info":[{"award-number":["HF-11-31-2013"]}],"id":[{"id":"https:\/\/ror.org\/00p991c53","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peritoneal adhesions are fibrous tissues formed after surgery. Both cytokines and transforming growth factors (\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    s) are involved in this process. The objective of this study was to investigate the cross talk between these entities. Peritoneal drainage fluid after surgery from patients and rodent models was examined by enzyme\u2010linked immunosorbent assay and fluorescence\u2010activated cell sorter. Data showed that the concentrations of interferon (\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    )\u2010\u03b3 and interleukin (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    )\u201017 reached their peaks 6\u201312 hours after surgery, whereas\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21 concentrations showed two postoperative peak time points at 2 and 72\u201396 hours. By neutralizing\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3,\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 6\u201312 hours, and\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21 72\u201396 hours after surgery, the degree of adhesion reduced significantly. However, neutralizing\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21 2 hours after surgery did not affect adhesion formation. Furthermore, in vitro studies showed that compared with the fibroblasts that were directly stimulated with\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21, the prestimulation of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 promoted plasminogen activator inhibitor\u20101 production while inhibiting tissue\u2010type plasminogen activator production. Moreover, additional stimulation with\n                    <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\n                    \u2010\u03b3 enhanced this effect. Together, these data indicate that\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 may promote adhesion formation by increasing the reaction of fibroblasts against\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21. Blocking\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 might have a therapeutic potential in preventing adhesion formation after surgery.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12203","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T04:18:58Z","timestamp":1401941938000},"page":"631-639","source":"Crossref","is-referenced-by-count":32,"title":["Role of IL\u201017 and TGF\u2010\u03b2 in peritoneal adhesion formation after surgical trauma"],"prefix":"10.1111","volume":"22","author":[{"given":"Geng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ende","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixiong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Surgery 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