{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:35:19Z","timestamp":1790847319287,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Autologous platelet\u2010rich plasma (PRP<\/jats:styled-content>) exerts positive therapeutic effects on hair thickness and density in patients with pattern hair loss. The aim of our study was to evaluate the efficacy of intra\u2010perifollicular autologous PRP<\/jats:styled-content> and polydeoxyribonucleotide (PDRN<\/jats:styled-content>) injections in treating female pattern hair loss (FPHL<\/jats:styled-content>). Twenty FPHL<\/jats:styled-content> patients were treated with a single session of PRP<\/jats:styled-content> injection, followed by 12 sessions of PDRN<\/jats:styled-content> intra\u2010perifollicular injection, along the scalp at weekly intervals. Additionally, another 20 FPHL<\/jats:styled-content> patients were treated with 12 sessions of PDRN<\/jats:styled-content> injection only. Meanwhile, one half of the backs of two rabbits was injected with the PRP<\/jats:styled-content> preparation, while the other half was injected with phosphate buffered saline as a control. Tissue samples from the rabbits were analyzed by real\u2010time polymerase chain reaction and W<\/jats:styled-content>estern blotting. Compared with baseline values, patients treated with PRP<\/jats:styled-content> and PDRN<\/jats:styled-content> injections exhibited clinical improvement in mean hair counts (23.2\u2009\u00b1\u200915.5%; p<\/jats:italic>\u2009<\u20090.001) and mean hair thickness (16.8\u2009\u00b1\u200910.8%; p<\/jats:italic>\u2009<\u20090.001). In addition, patients treated with the 12 sessions of intra\u2010perifollicular PDRN<\/jats:styled-content> injection alone also showed clinical improvement in mean hair counts (17.9\u2009\u00b1\u200913.2%; p<\/jats:italic>\u2009<\u20090.001) and mean hair thickness (13.5\u2009\u00b1\u200910.7%; p<\/jats:italic>\u2009<\u20090.001). Comparison analyses between the two groups revealed that combined therapy with PRP<\/jats:styled-content> and PDRN<\/jats:styled-content> induces greater improvement in hair thickness than treatment with PDRN<\/jats:styled-content> therapy alone (p<\/jats:italic>\u2009=\u20090.031), but not in hair counts (p<\/jats:italic>\u2009>\u20090.05). The pilot animal study revealed significant up\u2010regulation of WNT<\/jats:styled-content>, platelet\u2010derived growth factor, and fibroblast growth factor expression in rabbit skin treated with the PRP<\/jats:styled-content> preparation, compared with control skin. In conclusion, intra\u2010perifollicular injections of autologous PRP<\/jats:styled-content> and\/or PDRN<\/jats:styled-content> generate improvements in hair thickness and density in FPHL<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/wrr.12250","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:27:07Z","timestamp":1418984827000},"page":"30-36","source":"Crossref","is-referenced-by-count":79,"title":["Therapeutic efficacy of autologous platelet\u2010rich plasma and polydeoxyribonucleotide on female pattern hair loss"],"prefix":"10.1111","volume":"23","author":[{"given":"Si\u2010Hyung","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory of Disease Functional Genomics Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Department of Dermatology Yanbian University College of Medicine Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Soo","family":"Kang","sequence":"additional","affiliation":[{"name":"Kangskin Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Kangskin Dermatology Clinic Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2012.08.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117426"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01953.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000239560.29172.33"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02123.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02394.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12037"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12062"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01480.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01999.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90058-2"},{"key":"e_1_2_6_13_1","first-page":"184","article-title":"Growth 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