{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:46:00Z","timestamp":1790671560058,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CRADA between USUHS and Nitto Denko Technical Corporation","award":["G1708B"],"award-info":[{"award-number":["G1708B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A major complication for diabetic patients is chronic wounds due to impaired wound healing. It is well documented that visible red wavelengths can accelerate wound healing in diabetic animal models and patients. In vitro and in vivo diabetic models were used to investigate the effects of organic light emitting diode (OLED) irradiation on cellular function and cutaneous wound healing. Human dermal fibroblasts were cultured in hyperglycemic medium (glucose concentration 180\u2009mM) and irradiated with an OLED (623\u2009nm wavelength peak, range from 560 to 770\u2009nm, power density 7 or 10\u2009mW\/cm<jats:sup>2<\/jats:sup> at 0.2, 1, or 5\u2009J\/cm<jats:sup>2<\/jats:sup>). The OLED significantly increased total adenosine triphosphate concentration, metabolic activity, and cell proliferation compared with untreated controls in most parameters tested. For the in vivo experiment, OLED and laser (635\u2009\u00b1\u20095\u2009nm wavelength) treatments (10\u2009mW\/cm<jats:sup>2<\/jats:sup>, 5\u2009J\/cm<jats:sup>2<\/jats:sup> daily for a total of seven consecutive days) for cutaneous wound healing were compared using a genetic, diabetic rat model. Both treatments had significantly higher percentage of wound closure on day 6 postinjury and higher total histological scores on day 13 postinjury compared with control. No statistical difference was found between the two treatments. OLED irradiation significantly increased fibroblast growth factor\u20102 expression at 36\u2010hour postinjury and enhanced macrophage activation during initial stages of wound healing. In conclusion, the OLED and laser had comparative effects on enhancing diabetic wound healing.<\/jats:p>","DOI":"10.1111\/wrr.12258","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T12:02:45Z","timestamp":1423915365000},"page":"104-114","source":"Crossref","is-referenced-by-count":66,"title":["Organic light emitting diode improves diabetic cutaneous wound healing in rats"],"prefix":"10.1111","volume":"23","author":[{"given":"Xingjia","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics Uniformed Services University of the Health Sciences Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Alberico","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics Uniformed Services University of the Health Sciences Bethesda 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