{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:34:19Z","timestamp":1790274859815,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pressure ulcers (PUs) are injuries to the skin and underlying tissues, caused by sustained deformations and occur frequently in aged patients. Skin microtopography and stiffness affect the interaction of skin with contact surfaces contributing to PU development. We simulated immobility in 20 healthy females (mean age 69.9 years). Skin microtopography and stiffness were measured at the PU predilection sites before and after loading. Skin roughness decreased at the heels by 18.1% after 90 minutes (<jats:italic>p<\/jats:italic>\u2009=\u20090.022), but remained unchanged at the sacrum and the upper back. Structural elasticity and elastic deformations increased at all skin areas; changes over time were significant at the sacrum (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) and the heel, (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). The residual skin deformation increased at all skin areas after loading significantly at the sacrum (32.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and upper back (20.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). The structural \u201cbiological\u201d elasticity of the skin decreased significantly at the upper back after loading, but remained unchanged at the heels. All skin changes recovered after unloading. Results indicate that prolonged loading causes structural skin changes in humans in vivo in PU predilection sites. The pathogenesis of PUs is different at the heels, the sacral and upper back skin.<\/jats:p>","DOI":"10.1111\/wrr.12259","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T15:48:44Z","timestamp":1423928924000},"page":"37-43","source":"Crossref","is-referenced-by-count":21,"title":["Weight\u2010bearing\u2013induced changes in the microtopography and structural stiffness of human skin in vivo following immobility periods"],"prefix":"10.1111","volume":"23","author":[{"given":"Gabor","family":"Dobos","sequence":"first","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gefen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering Tel Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Blume\u2010Peytavi","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kottner","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy Charit\u00e9\u2010University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05311.x"},{"key":"e_1_2_7_4_1","first-page":"CD009958","article-title":"Repositioning for pressure ulcer prevention in adults (Review)","volume":"4","author":"Gillespie BM","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2012.08.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00373.x"},{"key":"e_1_2_7_7_1","volume-title":"Prevention and treatment of pressure ulcers: Clinical practice guideline. 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