{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:17:51Z","timestamp":1770895071710,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":108,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070009"],"award-info":[{"award-number":["81070009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>p120\u2010catenin (p120) is known as a cadherin\u2010associated protein that participates in tumor metastasis and invasion, as well as an anti\u2010inflammatory mediator. Recently, its anti\u2010inflammatory role is drawing increasing attention, but the regulatory mechanisms are still unknown. Here, we report that p120 modulated inflammatory responses partially depends on RhoA\/ROCK pathway in scratch\u2010induced injury in human bronchial epithelial cells (BECs). For the first time, we found that p120 was significantly reduced in BECs after scratching, which could induce interleukin\u20108 (IL\u20108) production through nuclear factor\u2010\u03baB (NF\u2010\u03baB) activation accompanied with I\u03baB\u03b1 phosphorylation. Over\u2010expression of p120 3A could inhibit NF\u2010\u03baB activation and IL\u20108 mRNA expression and protein synthesis after scratching, while p120 knockdown by small interfering RNA could promote NF\u2010\u03baB activation and IL\u20108 mRNA expression and protein synthesis after scratching. Furthermore, we found that RhoA was the binding partner of p120 in BECs. Although total RhoA and p120\u2010binded RhoA remained unchanged, the RhoA activity was increased after scratching. Chemical blockade of RhoA\/ROCK signaling (Y27632) inhibited scratch\u2010induced nuclear translocation of NF\u2010\u03baB p65. Over\u2010expression of p120 3A attenuated scratch\u2010induced RhoA activation, whereas silence of p120 significantly elevated scratch\u2010induced RhoA activation in BCEs. Conclusively, these results indicate an anti\u2010inflammatory effect of p120 in bronchial epithelial cells through its modulation of NF\u2010\u03baB signaling depending on RhoA\/ROCK pathway.<\/jats:p>","DOI":"10.1111\/wrr.12270","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T18:49:29Z","timestamp":1424285369000},"page":"231-240","source":"Crossref","is-referenced-by-count":13,"title":["p120\u2010Catenin modulating nuclear factor\u2010\u03baB activation is partially <scp>R<\/scp>ho<scp>A<\/scp>\/<scp>ROCK<\/scp>dependent in scratch injury"],"prefix":"10.1111","volume":"23","author":[{"given":"Shenghui","family":"Qin","sequence":"first","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhi","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naping","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease of Ministry of Health of China Wuhan Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/217580"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00249-12"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903162"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6257"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400234"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81698-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0323OC"},{"issue":"9","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1182\/blood.V88.9.3482.bloodjournal8893482","article-title":"Pyrrolidine dithiocarbamate inhibits the production of interleukin\u20106, interleukin\u20108 (IL\u20108), and granulocyte\u2010macrophage colony\u2010stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF\u2010\u03baB and AP\u20101 transcription factors activity","volume":"88","author":"MuAoz C","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/019021499270277"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.72.5.847"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.02.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00218-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.7.601"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6504"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90451-J"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.043"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807301105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019880"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.02.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001252"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.02.011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01148"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.3.567"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01974-06"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E12-05-0386"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23986"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.01.007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.099630"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.10.1.7507342"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00022.2004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.02.001"},{"issue":"1","key":"e_1_2_7_34_1","first-page":"79","article-title":"IQGAP1 promotes cell proliferation and is involved in a phosphorylation\u2010dependent manner in wound closure of bronchial epithelial cells","volume":"22","author":"Wang Y","year":"2008","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088064"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00435.2002"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.02.023"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.22.2723"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.2.629"},{"issue":"12","key":"e_1_2_7_40_1","first-page":"2439","article-title":"p120, a novel substrate of protein tyrosine kinase receptors and of p60v\u2010src, is related to cadherin\u2010binding factors beta\u2010catenin, plakoglobin and armadillo","volume":"7","author":"Reynolds AB","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199808)185:4<413::AID-PATH125>3.0.CO;2-K"},{"key":"e_1_2_7_42_1","first-page":"2633","article-title":"Expression of p120cas isoforms in human tumor cell lines identification of murine p120cas isoforms and heterogeneous","volume":"56","author":"Reynolds AB","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5325"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104901202"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2741\/4012"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2741\/3956"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:58:59Z","timestamp":1696190339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/wrr.12270"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12270","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}