{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:24:56Z","timestamp":1791015896679,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant 81170776"],"award-info":[{"award-number":["Grant 81170776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>The purpose of the study is to examine the safety and effectiveness of topical autologous platelet\u2010rich gel (APG) application on facilitating the healing of diabetic chronic refractory cutaneous ulcers. The study was designed as a prospective, randomized controlled trial between January 1, 2007 and December 31, 2011. Eligible inpatients at the Diabetic Foot Care Center of West China Hospital, Sichuan University (China) were randomly prescribed with a 12\u2010week standard treatment of ulcers (the control group) or standard treatment plus topical application APG (the APG group). The wound healing grades (primary endpoint), time to complete healing, and healing velocity within 12 weeks were monitored as short\u2010term effectiveness measurements, while side effects were documented safety endpoints. The rates of survival and recurrence within the follow up were recorded as long\u2010term effectiveness endpoints. Analysis on total diabetic ulcers (DUs) (<jats:italic>n<\/jats:italic>\u2009=\u2009117) and subgroup analysis on diabetic foot ulcers (DFUs) (<jats:italic>n<\/jats:italic>\u2009=\u2009103) were both conducted. Standard treatment plus APG treatment was statistically more effective than standard treatment (<jats:italic>p &lt;<\/jats:italic> 0.05 in both total DUs and subgroup of DFUs). The subjects defined as healing grade 1 were 50\/59 (84.8%) in total DUs and 41\/48 (85.4%) in DFUs in the APG group compared with 40\/58 (69.0%) and 37\/55 (67.3%) in the control group from intent to treat population. The Kaplan\u2010Meier time\u2010to\u2010healing were significantly different between the two groups (<jats:italic>p &lt;<\/jats:italic> 0.05 in both total DUs and subgroup of DFUs). No side effects were identified after topical APG application. The long\u2010term survival and recurrence rates were comparative between groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). This study shows that topical APG application plus standard treatment is safe and quite effective on diabetic chronic refractory cutaneous ulcers, compared with standard treatment.<\/jats:p>","DOI":"10.1111\/wrr.12294","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T09:54:36Z","timestamp":1428400476000},"page":"495-505","source":"Crossref","is-referenced-by-count":90,"title":["Autologous platelet\u2010rich gel for treatment of diabetic chronic refractory cutaneous ulcers: A prospective, randomized clinical trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Lan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanbing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjian","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Cochrane Centre Chinese EBM Centre, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Diabetic Foot Care Center, West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"S181","article-title":"International consensus on the diabetic foot and practical guidelines on the management and prevention of the diabetic foot by the international working group on the diabetic foot\/consultative section of the IDF","volume":"24","author":"International Working Group on the Diabetic Foot (IWGDF) Editorial Board","year":"2008","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198609000-00011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(91)90247-R"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0062"},{"key":"e_1_2_8_6_1","first-page":"227","article-title":"Current opinion about using the platelet\u2010rich gel in orthopaedics and trauma surgery","volume":"9","author":"Wrotniak M","year":"2007","journal-title":"Ortop Traumatol Rehabil"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-19824"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-4753(04)80029-2"},{"key":"e_1_2_8_9_1","first-page":"68","article-title":"Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet\u2010rich plasma gel for the treatment of diabetic foot ulcers","volume":"52","author":"Autologel Diabetic Foot Ulcer Study Group","year":"2006","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_8_10_1","unstructured":"FrieseG HertenM ScherbaumWA.The use of autologous platelet concentrate activated by autologous thrombin (APC+) is effective and safe in the treatment of chronic diabetic foot ulcers: a randomized controlled trial. 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