{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:20:18Z","timestamp":1791001218829,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foshan United Medical Technologies Ltd, Guangdong China","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chitosan, a natural polysaccharide derivate from chitin, offers a promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of a next\u2010generation KA01 chitosan wound dressing in facilitating the healing of nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study was conducted at three medical centers in China. A total of 90 patients (45 in test group and 45 in control group) with unhealed chronic wounds including pressure ulcers, vascular ulcers, diabetic foot ulcers, and wounds with minor infections, or at risk of infection, were treated with the next generation chitosan wound dressing as the test article or traditional vaseline gauze as a control. Baseline assessments were undertaken with the primary end point being wound area reduction. The secondary end points included pain reduction (using the NRS11 pain scale) at dressing change, wound exudate levels, wound depth and duration of the treatment. After 4 weeks treatment, the wound area reduction was significantly greater in the test group (65.97\u2009\u00b1\u20094.48%) than the control group (39.95\u2009\u00b1\u20094.48%). The average pain level in the test group was 1.12\u2009\u00b1\u20090.23 and 2.30\u2009\u00b1\u20090.23 in the control group. The wound depth was also lower in the test group 0.30\u2009\u00b1\u20090.48\u2009cm than the control group 0.54\u2009\u00b1\u20090.86\u2009cm. The level of exudate fell and the dressing could be removed integrally in both the test and control groups. The mean duration of the test group was 27.31\u2009\u00b1\u20095.37 days and control group 27.09\u2009\u00b1\u20096.44 days. No adverse events were reported in either group. In conclusion this open multicenter comparative prospective randomized clinical study has provided compelling evidence that the next generation chitosan wound dressing can enhance wound progression towards healing by facilitating wound reepithelialization and reducing the patients pain level. Furthermore the dressing was shown to be clinically safe and effective in the management of chronic wounds.<\/jats:p>","DOI":"10.1111\/wrr.12298","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T04:44:54Z","timestamp":1428122694000},"page":"518-524","source":"Crossref","is-referenced-by-count":51,"title":["An open multicenter comparative randomized clinical study on chitosan"],"prefix":"10.1111","volume":"23","author":[{"given":"Xiaohui","family":"Mo","sequence":"first","affiliation":[{"name":"Foshan United Medical Technologies Ltd Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cen","sequence":"additional","affiliation":[{"name":"Foshan United Medical Technologies Ltd Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Gibson","sequence":"additional","affiliation":[{"name":"Aspen Medical Europe Ltd Redditch United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Wang","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry Queen Mary University of London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Percival","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease and Surface Science Research Centre University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2000.3412"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02132997"},{"key":"e_1_2_7_4_1","first-page":"114","article-title":"Evaluation of a collagen\u2010alginate wound dressing in the management of diabetic foot ulcers","volume":"11","author":"Donaghue VM","year":"1998","journal-title":"Adv Wound Care"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.3.153"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.3.130"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000305429.01413.f8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.7.30525"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.3.136"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.4.28840"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00927.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.01.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/10_2010_93"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I9A192"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2007.05.043"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e32833a5ee4"},{"key":"e_1_2_7_18_1","first-page":"694","article-title":"Comparative study between chitin\/polyacrylic acid (PAA) dressing, lipido\u2010colloid absorbent dressing and alginate wound dressing: a pilot study in the treatment of partial\u2010thickness wound","volume":"93","author":"Angspatt A","year":"2010","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30000"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.59"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30522"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.10.053"},{"key":"e_1_2_7_23_1","unstructured":"Foshan United Medical Technologies Ltd Study report on file TP403 (rev 3)."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000112349.42549.b3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00466.x"},{"key":"e_1_2_7_26_1","first-page":"63","article-title":"Antibacterial activity of crab\u2010chitosan against Staphylococcus aureus and Escherichia coli","volume":"2","author":"Islam MM","year":"2011","journal-title":"J Adv Sci Res"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-14282009000300013"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:15:40Z","timestamp":1696187740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/wrr.12298"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12298","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]}}}