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In pursuit of a regenerative wound therapy, we developed a heparin\u2010based coacervate delivery system that provides controlled release of heparin\u2010binding epidermal growth factor (EGF)\u2010like growth factor (HB\u2010EGF) within the wound bed. In this study, we used a polygenic type 2 diabetic mouse model to evaluate the capacity of HB\u2010EGF coacervate to overcome the deficiencies of diabetic wound healing. In full\u2010thickness excisional wounds on NONcNZO10 diabetic mice, HB\u2010EGF coacervate enhanced the proliferation and migration of epidermal keratinocytes, leading to accelerated epithelialization. Furthermore, increased collagen deposition within the wound bed led to faster wound contraction and greater wound vascularization. Additionally, in vitro assays demonstrated that HB\u2010EGF released from the coacervate successfully increased migration of diabetic human keratinocytes. The multifunctional role of HB\u2010EGF in the healing process and its enhanced efficacy when delivered by the coacervate make it a promising therapy for diabetic wounds.<\/jats:p>","DOI":"10.1111\/wrr.12319","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T05:27:26Z","timestamp":1433222846000},"page":"591-600","source":"Crossref","is-referenced-by-count":47,"title":["Coacervate delivery of <scp>HB\u2010EGF<\/scp> accelerates healing of type 2 diabetic wounds"],"prefix":"10.1111","volume":"23","author":[{"given":"Noah R.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh 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