{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:06:06Z","timestamp":1788955566337,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Milan, Young researcher grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Starfish can regenerate entire arms following their loss by both autotomic and traumatic amputation. Although the overall regenerative process has been studied several times in different asteroid species, there is still a considerable gap of knowledge as far as the detailed aspects of the repair phase at tissue and cellular level are concerned, particularly in post\u2010traumatic regeneration. The present work is focused on the arm regeneration model in the Mediterranean red starfish <jats:italic>Echinaster sepositus<\/jats:italic>; to describe the early cellular mechanisms of arm regeneration following traumatic amputation, different microscopy techniques were employed. In <jats:italic>E. sepositus<\/jats:italic>, the repair phase was characterized by prompt wound healing by a syncytial network of phagocytes and re\u2010epithelialisation followed by a localized subepidermal oedematous area formation. Scattered and apparently undifferentiated cells, intermixed with numerous phagocytes, were frequently found in the wound area during these first stages of regeneration and extensive dedifferentiation phenomena were seen at the level of the stump, particularly in the muscle bundles. A true localized blastema did not form. Our results confirm that regeneration in asteroids mainly relies on morphallactic processes, consisting in extensive rearrangement of the existing tissues which contribute to the new tissues through cell dedifferentiation, redifferentiation, and\/or migration.<\/jats:p>","DOI":"10.1111\/wrr.12333","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T15:57:50Z","timestamp":1435161470000},"page":"611-622","source":"Crossref","is-referenced-by-count":30,"title":["Wound repair during arm regeneration in the red starfish <scp><i>E<\/i><\/scp><i>chinaster sepositus<\/i>"],"prefix":"10.1111","volume":"23","author":[{"given":"Yousra","family":"Ben Khadra","sequence":"first","affiliation":[{"name":"Laboratory of Genetics Biodiversity and Valorization of Bioresources Higher Institute of Biotechnology, University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Ferrario","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"},{"name":"King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences and Engineering Division Thuwal Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Said","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics Biodiversity and Valorization of Bioresources Higher Institute of Biotechnology, University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bonasoro","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Daniela","family":"Candia Carnevali","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Sugni","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Principles of regeneration","author":"Goss RJ.","year":"1969"},{"key":"e_1_2_7_3_1","volume-title":"Regeneration","author":"Mattson P.","year":"1976"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175336"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.04.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369371-6\/50018-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.12.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.06.016"},{"key":"e_1_2_7_9_1","first-page":"64","article-title":"Regeneration in echinoderms: repair, regrowth, cloning","volume":"3","author":"Candia Carnevali MD.","year":"2006","journal-title":"ISJ"},{"key":"e_1_2_7_10_1","volume-title":"eLS","author":"Candia Carnevali MD"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133609"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376366"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1998.0220"},{"key":"#cr-split#-e_1_2_7_14_1.1","unstructured":"DucatiCC Candia CarnevaliMD BarkerMF.Regenerative potential and fissiparity in the starfishCoscinasterias muricata. 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