{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:02:36Z","timestamp":1792098156069,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30872686"],"award-info":[{"award-number":["30872686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aims to investigate whether severe hypoxia and malnutrition in scar tissue play key roles to induce hypertrophic scar regression. And scar\u2010derived fibroblasts were treated with moderate\/severe hypoxia and malnutrition to model condition of proliferative and regressive scar (5%O<jats:sub>2<\/jats:sub>+5%FCS and 0.5%O<jats:sub>2<\/jats:sub>\u2009+ 0.5%FCS), and normoxia with well nutrition as control (10%O<jats:sub>2<\/jats:sub>\u2009+\u200910%FCS). Our results demonstrated that severe hypoxia and malnutrition resulted in significantly reduced cell viability and collagen production, as well as HIF\u20101, VEGF, TGF\u2010\u03b2<jats:sub>1<\/jats:sub>, and Bcl\u20102 protein expression when compared with control, and cell apoptosis occurred. Therefore, the severe hypoxia and malnutrition in scar tissue contribute to fibroblast inhibition and cell apoptosis, which is correlated with scar regression.<\/jats:p>","DOI":"10.1111\/wrr.12343","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T22:16:58Z","timestamp":1436912218000},"page":"664-671","source":"Crossref","is-referenced-by-count":18,"title":["Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Emily C.","family":"Lynam","sequence":"first","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation, Queensland University of Technology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation, Queensland University of Technology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Dawson","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation, Queensland University of Technology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqui","family":"Mcgovern","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation, Queensland University of Technology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zee","family":"Upton","sequence":"additional","affiliation":[{"name":"Tissue Repair and Regeneration Program Institute of Health and Biomedical Innovation, Queensland University of Technology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiQiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre General Hospital of Ningxia Medical University Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00921.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005083"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017859"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197910000-00007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"WangXQ LiuYK ChunQ Shu\u2010LiangL.Hyperactivity of fibroblasts and functional regression of endothelial cells contribute to microvessel occlusion in hypertrophic scarring.Microvasc res2009;77:204\u201311.","DOI":"10.1016\/j.mvr.2008.08.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12474"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.141"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23074"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00419.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.047"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03796.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2004.10.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.5.974"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.09.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2004.00310.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131227162215"},{"key":"e_1_2_6_18_1","first-page":"3959","article-title":"Proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood under the culture conditions of hypoxia and serum deprivation","volume":"124","author":"Fu WL","year":"2011","journal-title":"Chin Med J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890801986594"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700651"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12283"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2544"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/876363"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000063128.86981.B2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.04.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181bb4a07"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.11995"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031299"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.6.861"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03810"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03450"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4904842"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12343","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:28:15Z","timestamp":1695565695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/wrr.12343"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12343","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}