{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:27:37Z","timestamp":1757701657717},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the relationship between serum cystatin C levels and the prognosis of diabetic foot ulcerations (DFU). A population\u2010based cohort study involving 1018 patients with type 2 diabetes was conducted. These patients recruited and divided into two groups: nondiabetic foot ulcer group (NDF, <jats:italic>n<\/jats:italic>\u2009=\u2009865, 85.5%) and diabetic foot ulcer group (DFU, <jats:italic>n<\/jats:italic>\u2009=\u2009147, 14.5%).After a 1\u2010year\u2010follow\u2010up, DFUs were grouped into healing (<jats:italic>n<\/jats:italic>\u2009=\u2009110, 74.8%) and nonhealing (<jats:italic>n<\/jats:italic>\u2009=\u200937, 25.2%) group based on the clinical prognosis. Compared with the healing group, the nonhealing group were older, had long diabetic duration and had significantly increased serum cystatin C concentrations in DFU (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). After adjustments for age, diabetes duration, renal function and infection control, multiple logistical regression analysis revealed that cystatin C remained associated increased risk of undesirable DFU outcome (OR\u2009=\u20097.279, 95% CI: 1.299\u201340.784, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). When divided into quartiles according to cystatin C levels, the healing rate of Quartile 4 was significantly lower (57.9%) compared with other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The odd is ratio (OR) analysis showed that the risk of undesirable DFU outcome in Quartile 4 was significantly higher (OR\u2009=\u20094.554, 95% CI: 3.14\u20135.12, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) compared with that in Quartile 1. We concluded that there was a strong and independent association between serum cystatin C and diabetic foot ulceration prognosis, cystatin C\u2009&gt;\u20091.35 mg\/L predicts more than sixfold increased risk of incurable foot ulceration.<\/jats:p>","DOI":"10.1111\/wrr.12419","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T11:18:21Z","timestamp":1455189501000},"page":"560-567","source":"Crossref","is-referenced-by-count":3,"title":["High cystatin C levels predict undesirable outcome for diabetic foot ulcerations"],"prefix":"10.1111","volume":"24","author":[{"given":"Ligen","family":"Ai","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyun","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Multi\u2010disciplinary Collaborative Diabetic Foot Group of Shanghai Clinical Center of Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital, Department of Vascular Surgery The Multi\u2010disciplinary Collaborative Diabetic Foot Group of Shanghai Clinical Center of Diabetes, Shanghai Clinical Center of Trauma and Orthopedics, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungong","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Multi\u2010disciplinary Collaborative Diabetic Foot Group of Shanghai Clinical Center of Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital, Department of Interventional Radiology The Multi\u2010disciplinary Collaborative Diabetic Foot Group of Shanghai Clinical Center of Diabetes, Shanghai Clinical Center of Trauma and Orthopedics, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Multi\u2010disciplinary Collaborative Diabetic Foot Group of Shanghai Clinical Center of Diabetes, Shanghai Clinical Center of Trauma and Orthopedics, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxi","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Tang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Bao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology &amp; Metabolism Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Disease, Shanghai Institute for Diabetes, Shanghai Jiao\u2010Tong University Affiliated Sixth People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1007","article-title":"Diabetic foot ulcers. 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