{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:56:55Z","timestamp":1788346615613,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Commission European Union, European Social Funds","award":["POR Calabria FSE 2007\/2013"],"award-info":[{"award-number":["POR Calabria FSE 2007\/2013"]}]},{"name":"Region of Calabria (Taverna)","award":["NIH\/NIGMS 5P41 GM 103391-03 (Caprioli) and 1R01 AR056138-01A2 (Nanney)"],"award-info":[{"award-number":["NIH\/NIGMS 5P41 GM 103391-03 (Caprioli) and 1R01 AR056138-01A2 (Nanney)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The spatiotemporal analysis of the proteomic profile during human wound healing is a critical investigative step that can establish the complex interplay of molecular events that comprise the local response to burn injury. Partial\u2010thickness wound samples with adjacent \u201cnormal\u201d skin were collected from twenty\u2010one patients with burn wounds and examined across a time spectrum ranging from the acute injury period at 3, 6, 11 days to the later hypertrophic scar period at 7 and 15 months. The techniques used for histology\u2010directed tissue analyses highlighted inflammatory protein markers at the early time points after injury with diminished expression as burn wounds progressed into the proliferative phase. The datasets show the usefulness of MALDI MS and imaging mass spectrometry as discovery approaches to identify and map the cutaneous molecular sequence that is activated in response to the unique systemic inflammatory response following burn trauma. This information has the potential to define the unique factors that predispose human burn victims to disfiguring hypertrophic scar formation.<\/jats:p>","DOI":"10.1111\/wrr.12450","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T08:42:43Z","timestamp":1464943363000},"page":"775-785","source":"Crossref","is-referenced-by-count":11,"title":["Imaging mass spectrometry for accessing molecular changes during burn wound healing"],"prefix":"10.1111","volume":"24","author":[{"given":"Domenico","family":"Taverna","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Della Calabria Arcavacata Di Rende Italy"},{"name":"Mass Spectrometry Research Center, Vanderbilt School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonda C.","family":"Pollins","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Vanderbilt School of Medicine Nashville 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