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It could be associated with genetic variation. We have previously shown that <jats:italic>NOS1AP<\/jats:italic> variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if <jats:italic>NOS1AP<\/jats:italic> variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that <jats:italic>NOS1AP<\/jats:italic> variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it <jats:italic>NOS1AP<\/jats:italic> might be associated with a functional impairment.<\/jats:p>","DOI":"10.1111\/wrr.12564","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T15:42:38Z","timestamp":1501342958000},"page":"733-736","source":"Crossref","is-referenced-by-count":13,"title":["<i>NOS1AP<\/i> genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem\/progenitor cells"],"prefix":"10.1111","volume":"25","author":[{"given":"David J.","family":"Margolis","sequence":"first","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania, Philadelphia  Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Hampton","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania, Philadelphia  Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Hoffstad","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania, Philadelphia  Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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