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The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an endoplasmic reticulum transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Using luciferase reporter mice for <jats:italic>Xbp1<\/jats:italic> splicing, we showed that IRE1 was up\u2010regulated during excisional wound healing at the time in wound healing consistent with that of the proliferative phase, when the majority of protein synthesis for cellular proliferation and matrix deposition occurs. Furthermore, using a small molecule inhibitor of IRE1 we demonstrated that inhibition of IRE1 led to decreased scar formation in treated mice. Results were recapitulated in a hypertrophic scar mouse model. These data help provide a cellular pathway to target in the treatment of hypertrophic scarring and keloid disorders.<\/jats:p>","DOI":"10.1111\/wrr.12603","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T05:48:33Z","timestamp":1515563313000},"page":"964-971","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of IRE1 results in decreased scar formation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-1864","authenticated-orcid":false,"given":"Tatiana V.","family":"Boyko","sequence":"first","affiliation":[{"name":"Department of Surgery Stanford University School of Medicine Stanford California"},{"name":"Department of Surgery University at Buffalo, SSUNY Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Bam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine Stanford 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