{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:58Z","timestamp":1740126358046,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571491","31771608"],"award-info":[{"award-number":["31571491","31771608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15PJ1407200"],"award-info":[{"award-number":["15PJ1407200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004204","name":"Tongji University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ontogenetic decline of regeneration capacity in the anuran amphibian <jats:italic>Xenopus<\/jats:italic> makes it an excellent model for regeneration studies. However, the cause of the regeneration ability decline is not fully understood. MicroRNAs regulate animal development and have been indicated in various regeneration situations. However, little is known about the role of microRNAs during limb regeneration in <jats:italic>Xenopus<\/jats:italic>. This study investigates the effect of Dicer, an enzyme responsible for microRNA maturation, on limb development and regeneration in <jats:italic>Xenopus<\/jats:italic>. <jats:italic>Dicer<\/jats:italic> is expressed in the developing <jats:italic>Xenopus<\/jats:italic> limbs and is up\u2010regulated after limb amputation during both regeneration\u2010competent and regeneration\u2010deficient stages of tadpole development. Inactivation of Dicer in early (NF stage 53) tadpole limb buds leads to shorter tibulare\/fibulare formation but does not affect limb regeneration. However, in late\u2010stage, regeneration\u2010deficient tadpole limbs (NF stage 57), Dicer inactivation restores the regeneration blastema and stimulates limb regeneration. Thus, our results demonstrated that <jats:italic>Xenopus<\/jats:italic> limb regeneration can be stimulated by the inactivation of Dicer in nonregenerating tadpoles, indicating that microRNAs present in late\u2010stage tadpole limbs may be involved in the ontogenetic decline of limb regeneration in <jats:italic>Xenopus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/wrr.12619","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T10:42:45Z","timestamp":1518864165000},"page":"46-53","source":"Crossref","is-referenced-by-count":2,"title":["Dicer inactivation stimulates limb regeneration ability in <i>Xenopus laevis<\/i>"],"prefix":"10.1111","volume":"26","author":[{"given":"Mengshi","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology Tongji University Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology Tongji University Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology Tongji University Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, Department of Genetics Cell Biology and Development University of Minnesota Minneapolis 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