{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:49:13Z","timestamp":1770745753815,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic wounds often exist in a heightened state of inflammation whereby excessive inflammatory cells release high levels of proteases and reactive oxygen species (ROS). While low levels of ROS play a fundamental role in the regulation of normal wound healing, their levels need to be tightly regulated to prevent a hostile wound environment resulting from excessive levels of ROS. Infection amplifies the inflammatory response, augmenting levels of ROS which creates additional tissue damage that supports microbial growth. Antimicrobial dressings are used to combat infection; however, the effects of these dressing on the wound environment and healing independent of infection are rarely assessed. Cytotoxic or adverse effects on healing may exacerbate the hostile wound environment and prolong healing. Here we assessed the effect on healing independent of infection of silver oxysalts which produce higher oxidative states of silver (Ag<jats:sup>2+<\/jats:sup>\/Ag<jats:sup>3+<\/jats:sup>). Silver oxysalts had no adverse effect on fibroblast scratch wound closure whilst significantly promoting closure of keratinocyte scratch wounds (34% increase compared with control). Furthermore, dressings containing silver oxysalts accelerated healing of full\u2010thickness incisional wounds in wild\u2010type mice, reducing wound area, promoting reepithelialization, and dampening inflammation. We explored the mechanisms by which silver oxysalts promote healing and found that unlike other silver dressings tested, silver oxysalt dressings catalyze the breakdown of hydrogen peroxide to water and oxygen. In addition, we found that silver oxysalts directly released oxygen when exposed to water. Collectively, these data provide the first indication that silver oxysalts promote healing independent of infection and may regulate oxidative stress within a wound through catalysis of hydrogen peroxide.<\/jats:p>","DOI":"10.1111\/wrr.12627","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T12:06:41Z","timestamp":1520856401000},"page":"144-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Silver oxysalts promote cutaneous wound healing independent of infection"],"prefix":"10.1111","volume":"26","author":[{"given":"Helen A.","family":"Thomason","sequence":"first","affiliation":[{"name":"Crawford Healthcare Ltd. Knutsford Cheshire United Kingdom"},{"name":"Faculty of Biology, Medicine and Health The University of Manchester Manchester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie M.","family":"Lovett","sequence":"additional","affiliation":[{"name":"Crawford Healthcare Ltd. Knutsford Cheshire United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla J.","family":"Spina","sequence":"additional","affiliation":[{"name":"Exciton Technologies Inc. Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Crawford Healthcare Ltd. Knutsford Cheshire United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"McBain","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health The University of Manchester Manchester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Hardman","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Hull Hull United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.11.552"},{"key":"e_1_2_6_3_1","first-page":"17","article-title":"Are your wound management choices costing you money?","volume":"29","author":"Morgan T.","year":"2015","journal-title":"J Commun Nurs"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00543.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2001.00178.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.8.30796"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12557"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01195.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009539"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1451"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.27.9.889"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(87)80030-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2006.00265.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/644732"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.02.005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2004.11.014"},{"issue":"5","key":"e_1_2_6_17_1","first-page":"41","article-title":"A guide to the properties and uses of silver dressings in wound care","volume":"20","author":"Lansdown AB.","year":"2005","journal-title":"Prof Nurse"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00190.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.21"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2003.09.030"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115611969"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2004.11732656"},{"key":"e_1_2_6_23_1","first-page":"293","article-title":"Silver dressings improve diabetic wound healing without reducing bioburden","volume":"25","author":"Finley PJ","year":"2013","journal-title":"Wounds"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05177-14"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2017.1322586"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.291"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12148"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00321.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1149\/1.1723498"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2015.02.037"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200600171"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049215"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08119"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24683"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.09.002"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.003403"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1128\/aem.62.7.2598-2602.1996","article-title":"A novel strategy for control of microbial biofilms through generation of biocide at the biofilm\u2010surface interface","volume":"62","author":"Wood P","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.2.53"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12069"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:53:51Z","timestamp":1694696031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/wrr.12627"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12627","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"2017-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}