{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:23:14Z","timestamp":1791872594073,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venous insufficiency is the most common cause of leg ulceration, but the impact of venous leg ulceration on health\u2010related quality of life has not been adequately assessed. This study compared data from randomized controlled trials to population norms obtained from a large national population survey. We combined the baseline Short Form\u201036 (SF\u201036) version 1 data from two New Zealand randomized controlled trials that recruited participants with VLU and compared the pooled data to the population scores obtained from the New Zealand Health Survey using general linear regression to adjust for age, sex, and ethnicity differences between the cohorts. Baseline SF\u201036 scores obtained from 618 trial participants were compared to the SF\u201036 scores obtained from the 12,529 participants in the New Zealand Health Survey. Participants with VLU had significantly lower crude SF\u201036 scores across all eight SF\u201036 domains, but there was interaction between age and group. Adjusted mean differences for participants aged 65 years or younger were \u221225.8, \u221232.1, \u221221.2, \u22129.6, \u22127.6, \u221223.9, \u221221.5, and \u22129.3, respectively, for Physical Functioning, Role Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role Emotional, and Mental Health whereas the adjusted mean differences for older participants were \u221215.7, \u221223.8, \u221213.8, \u22120.3 (nonsignificant), \u22124.6, \u221215.3, \u221221.2, and \u22126.6. This study is the first to compare a VLU population to norms from a general population survey and the first to show VLU interacts with age creating stronger impact in younger patients compared their age cohort. Younger patients may have need of more pastoral care as a consequence.<\/jats:p>","DOI":"10.1111\/wrr.12636","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T10:30:30Z","timestamp":1531823430000},"page":"206-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of venous leg ulceration on health\u2010related quality of life: A synthesis of data from randomized controlled trials compared to population norms"],"prefix":"10.1111","volume":"26","author":[{"given":"Andrew","family":"Jull","sequence":"first","affiliation":[{"name":"School of Nursing University of Auckland Auckland New Zealand"},{"name":"National Institute for Health Innovation University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Muchoney","sequence":"additional","affiliation":[{"name":"National Institute for Health Innovation University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Parag","sequence":"additional","affiliation":[{"name":"National Institute for Health Innovation University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wadham","sequence":"additional","affiliation":[{"name":"National Institute for Health Innovation University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bullen","sequence":"additional","affiliation":[{"name":"National Institute for Health Innovation University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Waters","sequence":"additional","affiliation":[{"name":"Auckland District Health Board Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"571","article-title":"The impact of leg ulcers on patients' quality of life","volume":"10","author":"Charles H.","year":"1995","journal-title":"Prof Nurs"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.1995.tb03110.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1997.6.5.222"},{"key":"e_1_2_11_5_1","first-page":"158","article-title":"Painful venous ulcers: themes and stories about living with the pain and suffering","volume":"25","author":"Krasner D.","year":"1998","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2001.10.9.26318"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1994.3.6.294"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693308803300603"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70134-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-0303(97)90004-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-6712.2001.00018.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(05)80313-5"},{"key":"e_1_2_11_13_1","unstructured":"NelzenO BergqvistD LindhagenA.General health socioeconomic factors and lifestyle in patients with chronic lower limb ulceration: a case\u2010control questionnaire study [PhD]. Uppsala University 1997."},{"key":"e_1_2_11_14_1","first-page":"374","article-title":"Can different primary care databases produce comparable estimates of burden of disease: results of a study exploring venous leg ulceration","volume":"32","author":"Petherick ES","year":"2015","journal-title":"Fam Pract"},{"key":"e_1_2_11_15_1","volume-title":"SF\u201036 health survey: manual & interpretation guide","author":"Ware J","year":"1993"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2010.03269.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05568.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327655JCHN1701_01"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6059"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.12864"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5157"},{"key":"e_1_2_11_22_1","volume-title":"Leg ulcers; a problem\u2010based learning approach","author":"Morison MJ","year":"2007"},{"key":"e_1_2_11_23_1","volume-title":"Leg ulcers: a problem\u2010based learning approach","author":"Nelzen OP.","year":"2007"},{"key":"e_1_2_11_24_1","volume-title":"A portrait of health: key results of the 2002\/03 New Zealand health survey","author":"Ministry of Health","year":"2004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01282.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008992006845"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh087"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00556.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(00)00083-6"},{"key":"e_1_2_11_30_1","first-page":"23","article-title":"Practical guidelines for assessing clinical significance of health\u2010related quality of life changes within clinical trials","volume":"37","author":"Sloan J","year":"2003","journal-title":"Ther Innov Regul Sci"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-2751-9"},{"key":"e_1_2_11_32_1","first-page":"91","article-title":"Measuring health related quality of life in patients with chronic leg ulcers","volume":"8","author":"Price P","year":"1996","journal-title":"Wounds"},{"key":"e_1_2_11_33_1","first-page":"26","article-title":"Assessing quality of life in patients with chronic venous leg ulceration using the Medical Outcomes Short Form\u201036 questionnaire","volume":"49","author":"Franks PJ","year":"2003","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_11_34_1","volume-title":"Modern epidemiology","author":"Rothman K","year":"1998"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta8290"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b773"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"d1092","DOI":"10.1136\/bmj.d1092","article-title":"Use of weekly, low dose, high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised controlled trial","volume":"342","author":"Watson JM","year":"2011","journal-title":"BMJ"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6955-10-20"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04327.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta18570"},{"key":"e_1_2_11_41_1","first-page":"16","article-title":"A prospective, randomized, controlled trial comparing the effects of noncontact, low\u2010frequency ultrasound to standard care in healing venous leg ulcers","volume":"61","author":"Gibbons GW","year":"2015","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12571"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:54:18Z","timestamp":1694696058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/wrr.12636"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12636","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"2017-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}