{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:00:22Z","timestamp":1777561222818,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":237,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108015"],"award-info":[{"award-number":["81120108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertrophic scar pain, pruritus, and paresthesia symptoms are major and particular concerns for burn patients. However, because no effective and satisfactory methods exist for their alleviation, the clinical treatment for these symptoms is generally considered unsatisfactory. Therefore, their risk factors should be identified and prevented during management. We reviewed the medical records of 129 postburn hypertrophy scar patients and divided them into two groups for each of three different symptoms based on the University of North Carolina \u201c4P\u201d Scar Scale: patients with scar pain requiring occasional or continuous pharmacological intervention (HSc pain, <jats:italic>n<\/jats:italic>\u2009=\u200975) vs. patients without such scar pain (No HSc pain, <jats:italic>n<\/jats:italic>\u2009=\u200954); patients with scar pruritus requiring occasional or continuous pharmacological intervention (HSc pruritus, <jats:italic>n<\/jats:italic>\u2009=\u200963) vs. patients without such scar pruritus (No HSc pruritus, <jats:italic>n<\/jats:italic>\u2009=\u200966); patients with scar paresthesia that influenced the patients\u2019 daily activities (HSc paresthesia, <jats:italic>n<\/jats:italic>\u2009=\u200931) vs. patients without such scar paresthesia (No HSc paresthesia, <jats:italic>n<\/jats:italic>\u2009=\u200998). Three multivariable logistic regression models were built, respectively, to identify the risk factors for hypertrophic burn scar pain, pruritus, and paresthesia development. Multivariable analysis showed that hypertrophic burn scar pain development requiring pharmacological intervention was associated with old age (odds ratio [OR]\u2009=\u20091.046; 95% confidence interval [CI], 1.011\u20131.082, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), high body mass index (OR\u2009=\u20091.242; 95%CI, 1.068\u20131.445, <jats:italic>p<\/jats:italic>\u2009=\u20090.005), 2\u20135\u2010mm\u2010thick postburn hypertrophic scars (OR\u2009=\u20093.997; 95%CI, 1.523\u201310.487, <jats:italic>p<\/jats:italic>\u2009=\u20090.005), and 6\u201312\u2010month postburn hypertrophic scars (OR\u2009=\u20094.686; 95%CI, 1.318\u201316.653, <jats:italic>p<\/jats:italic>\u2009=\u20090.017). Hypertrophic burn scar pruritus development requiring pharmacological intervention was associated with smoking (OR\u2009=\u20093.239; 95%CI, 1.380\u20137.603; <jats:italic>p<\/jats:italic>\u2009=\u20090.007), having undergone surgical operation (OR\u2009=\u20092.236; 95%CI, 1.001\u20134.998; <jats:italic>p<\/jats:italic>\u2009=\u20090.049), and firm scars (OR\u2009=\u20093.317; 95%CI, 1.237\u20138.894; <jats:italic>p<\/jats:italic>\u2009=\u20090.017). Finally, hypertrophic burn scar paresthesia development which affected the patients\u2019 daily activities was associated with age (OR\u2009=\u20091.038; 95%CI, 1.002\u20131.075; <jats:italic>p<\/jats:italic>\u2009=\u20090.040), fire burns (OR\u2009=\u20090.041; 95%CI, 0.005\u20130.366; <jats:italic>p<\/jats:italic>\u2009=\u20090.004, other burns vs. flame burns), and banding and contracture scars (OR\u2009=\u20094.705; 95%CI, 1.281\u201317.288, <jats:italic>p<\/jats:italic>\u2009=\u20090.020).<\/jats:p>","DOI":"10.1111\/wrr.12637","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T19:17:11Z","timestamp":1525288631000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk factors for hypertrophic burn scar pain, pruritus, and paresthesia development"],"prefix":"10.1111","volume":"26","author":[{"given":"Yongqiang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Xiangya Hospital, Central South University  Changsha Hunan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery The Second Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery The Second Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery Changhai Hospital, Second Military Medical University  Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31406-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00083"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000103"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(90)90046-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34406.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199005000-00014"},{"key":"e_1_2_6_9_1","first-page":"519","article-title":"Laser resurfacing and remodeling of hypertrophic burn scars: the results of a large, prospective, before\u2010after cohort study, with long\u2010term follow\u2010up","volume":"260","author":"Hultman CS","year":"2014","journal-title":"Ann Surg"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.outlook.2017.07.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(08)11"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000268"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000819"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.12.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1219-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182644c25"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00784.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012115.x-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10393.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137563"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1920OC"},{"key":"e_1_2_6_22_1","first-page":"95","article-title":"Itching following burns: epidemiology and predictors","volume":"158","author":"Loey NE","year":"2008","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000156151.54042.DA"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31816a9f6f"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.101"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12665"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1011"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.04.006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181e3b804"},{"key":"e_1_2_6_30_1","first-page":"717","article-title":"Nerve outgrowth and neuropeptide expression during the remodeling of human burn wound scars","volume":"27","author":"Altun V","year":"2001","journal-title":"A 7\u2010month follow\u2010up study of 22 patients. 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