{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:12:30Z","timestamp":1751688750525,"version":"3.41.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Atrial natriuretic peptide (ANP) is a powerful vasodilating peptide secreted by cardiac muscle cells, and endothelial progenitor cells (EPCs) have been reported to stimulate cutaneous wound healing by mediating angiogenesis. To determine whether ANP can promote the EPC\u2010mediated repair of injured tissues, we examined the effects of ANP on the angiogenic properties of EPCs and on cutaneous wound healing. In vitro, ANP treatment enhanced the migration, proliferation, and endothelial tube\u2010forming abilities of EPCs. Furthermore, small interfering RNA\u2010mediated silencing of natriuretic peptide receptor\u20101, which is a receptor for ANP, abrogated ANP\u2010induced migration, tube formation, and proliferation of EPCs. In a murine cutaneous wound model, administration of either ANP or EPCs had no significant effect on cutaneous wound healing or angiogenesis in vivo, whereas the coadministration of ANP and EPCs synergistically potentiated wound healing and angiogenesis. In addition, ANP promoted the survival and incorporation of transplanted EPCs into newly formed blood vessels in wounds. These results suggest ANP accelerates EPC\u2010mediated cutaneous wound healing by promoting the angiogenic properties and survival of transplanted EPCs.<\/jats:p>","DOI":"10.1111\/wrr.12641","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T11:05:52Z","timestamp":1527332752000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Atrial natriuretic peptide accelerates human endothelial progenitor cell\u2013stimulated cutaneous wound healing and angiogenesis"],"prefix":"10.1111","volume":"26","author":[{"given":"Tae Wook","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physiology Pusan National University School of Medicine Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Woo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Physiology Pusan National University School 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