{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:42:23Z","timestamp":1783723343480,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":116,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["13\/802"],"award-info":[{"award-number":["13\/802"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin II via AT<jats:sub>1<\/jats:sub> receptor is known to play a key role in stimulation of fibrosis. A pilot placebo controlled single blind study was carried out on patients with hypertrophic scars and keloids. A total of 37 adult volunteers were randomly assigned into losartan 5% or placebo treatment groups. The treatment was performed twice a day for three months and a 6\u2010month follow\u2010up. The treatment was evaluated using Vancouver scar scale method. Totally, 30 participants were analyzed (Losartan ointment <jats:italic>n =<\/jats:italic> 20; placebo ointment <jats:italic>n =<\/jats:italic> 10; seven placebo volunteers left the study because they thought the treatment was not effective for them). In the losartan group, VSS scores dropped significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) both in keloid and hypertrophic scar patients. Vascularity and pliability were significantly reduced by losartan treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). It can be concluded that losartan potassium ointment (5%) can alleviate the keloid and hypertrophic scar.<\/jats:p>","DOI":"10.1111\/wrr.12648","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T07:58:42Z","timestamp":1534060722000},"page":"340-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Losartan ointment relieves hypertrophic scars and keloid: A pilot study"],"prefix":"10.1111","volume":"26","author":[{"given":"Keshvad","family":"Hedayatyanfard","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-8119","authenticated-orcid":false,"given":"Seyed Ali","family":"Ziai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Shahid Beheshti University 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.0139.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63422-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2003.12.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089129.51288.BA"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164113485461"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000182343.99694.28"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21600-w"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819a34db"},{"key":"e_1_2_6_11_1","first-page":"4979","article-title":"Role 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