{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:28:06Z","timestamp":1788272886413,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wound Management Innovation Cooperative Research Centre"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Over 30% of venous leg ulcers do not heal despite evidence\u2010based treatment. This study aimed to determine the effectiveness of Hyperbaric Oxygen Therapy (HBOT) as an adjunct treatment for nonhealing venous leg ulcers. A randomized, double\u2010blind, parallel group, placebo\u2010controlled trial was undertaken in three hyperbaric medicine units. Adults with a venous leg ulcer, Transcutaneous Oxygen Measurement indicative of a hypoxic wound responsive to oxygen challenge, and without contraindications for HBOT; were eligible. Of 84 eligible patients, 10 refused and 74 enrolled. 43 participants achieved over 50% ulcer Percent Area Reduction (PAR) after four weeks of evidence\u2010based care and were thus excluded from the intervention phase. Thirty\u2010one participants were randomized to either 30 HBOT treatments (100% oxygen at 2.4 atmospheres absolute (ATA) for 80 minutes), or 30 \u201cplacebo\u201d treatments, receiving a validated \u201csham\u201d air protocol, initially pressurized to 1.2ATA, then cycled between 1.05\u20131.2ATA for eight minutes before settling at 1.05ATA. The primary outcome was numbers in each group completely healed. Secondary outcomes were ulcer PAR, pain and quality of life, 12 weeks after commencing interventions. The participants\u2019 mean age was 70 years (standard deviation (SD) 12.9) and median ulcer duration at enrolment was 62 weeks (range 4\u20133120). At 12 weeks, there was no significant difference between groups in the numbers completely healed. The HBOT intervention group had a mean of 95 (SD 6.53) ulcer PAR, compared to 54 (SD 67.8) mean PAR for the placebo group (<jats:italic>t<\/jats:italic>\u2009=\u2009\u22122.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.042, mean difference \u221240.8, SE 18.2) at 12 weeks. HBOT may improve refractory healing in venous leg ulcers, however patient selection is important. In this study, HBOT as an adjunct treatment for nonhealing patients returned indolent ulcers to a healing trajectory.<\/jats:p>","DOI":"10.1111\/wrr.12657","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:40:00Z","timestamp":1534952400000},"page":"324-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"26","author":[{"given":"Kenneth R.","family":"Thistlethwaite","sequence":"first","affiliation":[{"name":"Royal Brisbane &amp; Women's Hospital Hyperbaric Medicine Service  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-2731","authenticated-orcid":false,"given":"Kathleen J.","family":"Finlayson","sequence":"additional","affiliation":[{"name":"School of Nursing, Institute of Health and Biomedical Innovation Queensland University of Technology  Kelvin Grove Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. David","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Diving &amp; Hyperbaric Medicine Royal Hobart Hospital; School of Medicine, University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bebe","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Diving &amp; Hyperbaric Medicine Royal Hobart Hospital  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Diving and Hyperbaric Medicine Prince of Wales Hospital, Sydney; Prince of Wales Medical School, University of NSW  Randwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Kay","sequence":"additional","affiliation":[{"name":"Wesley Centre for Hyperbaric Medicine  Auchenflower Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Occupational Therapy, Central Queensland University  Bundaberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"14","article-title":"The prevalence of leg ulceration: a review of the literature","volume":"3","author":"Briggs M","year":"2003","journal-title":"EWMA 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