{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:45:49Z","timestamp":1790765149785,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":113,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"miRagen Therapeutics, Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>There is a strong unmet need for new therapeutics to accelerate wound healing across both chronic and acute indications. It is well established that local tissue hypoxia, vascular insufficiency, and\/or insufficient angiogenesis contribute to inadequate wound repair in the context of diabetic foot ulcers as well as to other chronic wounds such as venous stasis and pressure ulcers. microRNA\u201092a\u20103p (miR\u201092a) is a potent antiangiogenic miRNA whose inhibition has led to increases in angiogenesis in multiple organ systems, resulting in an improvement in function following myocardial infarction, limb ischemia, vascular injury, and bone fracture. Due to their pro\u2010angiogenic effects, miR\u201092a inhibitors offer potential therapeutics to accelerate the healing process in cutaneous wounds as well. This study investigated the effect of a development stage locked nucleic acid\u2010modified miR\u201092a inhibitor, MRG\u2010110, in excisional wounds in db\/db mice and in normal pigs. In both acute and chronic wounds, MRG\u2010110 increased granulation tissue formation as assessed by histology, angiogenesis as assessed by immunohistochemistry and tissue perfusion, and wound healing as measured by time to closure and percent closure over time. The effects of MRG\u2010110 were greater than those that were observed with the positive controls rhVEGF\u2010165 and rhPDGF\u2010BB, and MRG\u2010110 was at least additive with rhPDGF\u2010BB when co\u2010administered in db\/db mouse wounds. MRG\u2010110 was found to up\u2010regulate expression of the pro\u2010angiogenic miR\u201092a target gene integrin alpha 5 in vitro in both human vascular endothelial cells and primary human skin fibroblasts and in vivo in mouse skin, demonstrating its on\u2010target effects in vitro and in vivo. Additional safety endpoints were assessed in both the mouse and pig studies with no safety concerns noted. These studies suggest that MRG\u2010110 has the potential to accelerate both chronic and acute wound healing and these data provide support for future clinical trials of MRG\u2010110.<\/jats:p>","DOI":"10.1111\/wrr.12660","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T15:01:52Z","timestamp":1534518112000},"page":"311-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["A synthetic microRNA\u201092a inhibitor (MRG\u2010110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-2847","authenticated-orcid":false,"given":"Corrie L.","family":"Gallant\u2010Behm","sequence":"first","affiliation":[{"name":"miRagen Therapeutics, Inc.  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