{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:39:00Z","timestamp":1790800740703,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Foot ulcer is a major complication of diabetes mellitus and often precedes leg amputation. Among the different methods to achieve ulcer healing, the use of platelet\u2010rich plasma, which is rich in multiple growth factors and cytokines and may have similarities to the natural wound healing process, is gaining in popularity. A systematic review with meta\u2010analyses was performed to evaluate the safety and clinical effectiveness of platelet\u2010rich plasma for the treatment of diabetic foot ulcers compared to standard treatment or any other alternative therapy. The electronic databases Medline, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials were consulted in March 2017 with no restrictions placed on the publication date. Predefined criteria were used to determine inclusion of studies and to assess their methodologic quality. Eight randomized clinical trials and two prospective longitudinal\u2010observational studies with control group were included. Platelet\u2010rich plasma treatment increased the likelihood of chronic wound healing (RR = 1.32; 95% CI: 1.11, 1.57, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 15%) while the volume of the ulcer (MD = 0.12 cm<jats:sup>2<\/jats:sup>; 95% CI: 0.08, 0.16; <jats:italic>p<\/jats:italic> &lt; 0.01; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%) and time to complete wound healing (MD = \u221211.18 days; 95% CI: \u221220.69, \u22121.68; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 53%) decreased. Regarding safety profile, platelet\u2010rich plasma did not differ from standard treatment in terms of probability of occurrence of wound complications (RR = 0.57; 95% CI: 0.25, 1.28; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%) or recurrences (RR = 2.76; 95% CI: 0.23, 33.36; <jats:italic>p<\/jats:italic> = 0.43; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 82%) but it decreased the rate of adverse events (RR = 0.80; 95% CI: 0.66, 0.96; <jats:italic>p<\/jats:italic> = 0.02; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%). Cumulative meta\u2010analysis revealed that there is enough evidence to demonstrate a statistically significant benefit. However, studies included presented serious methodologic flaws. According to the results, platelet\u2010rich plasma could be considered a candidate treatment for nonhealing of diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/wrr.12690","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T21:22:54Z","timestamp":1545427374000},"page":"170-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Platelet\u2010rich plasma for the treatment of diabetic foot ulcers: A meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Tasmania","family":"del Pino\u2010Sede\u00f1o","sequence":"first","affiliation":[{"name":"Department of Clinic Psicology, Psicobiology and Methodoloy La Laguna University  Santa Cruz de Tenerife Spain"},{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Trujillo\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Canary Islands Foundation of Health Research (FUNCANIS)  El Rosario, Santa Cruz de Tenerife Spain"},{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"},{"name":"Center for Biomedical Research of the Canary Islands (CIBICAN)  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Andia","sequence":"additional","affiliation":[{"name":"BioCruces Bizkaia Health Research Institute University Hospital of Cruces  Barakaldo Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Arag\u00f3n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit La Paloma Hospital  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Herrera\u2010Ramos","sequence":"additional","affiliation":[{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Canary Islands Foundation of Health Research (FUNCANIS)  El Rosario, Santa Cruz de Tenerife Spain"},{"name":"Spanish Network of Health Technology Assessment (RedETS)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Iruzubieta Barrag\u00e1n","sequence":"additional","affiliation":[{"name":"Health Services and Chronic Diseases Research Network (REDISSEC)  Spain"},{"name":"Center for Biomedical Research of La Rioja (CIBIR) La Rioja Health Service  Logro\u00f1o Spain"},{"name":"Pre\u2010Departmental Nursing Unit Nursing School, La Rioja University  Logro\u00f1o 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