{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:00:06Z","timestamp":1783695606512,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003503","name":"Nederlandse Brandwonden Stichting","doi-asserted-by":"publisher","award":["12.109"],"award-info":[{"award-number":["12.109"]}],"id":[{"id":"10.13039\/501100003503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although partial thickness burns are the most frequently reported burn injuries, there is no consensus on the optimal treatment. The objective of this study was to compare the clinical effectiveness and scar quality of Flaminal\u00ae Forte to silver sulfadiazine (Flamazine\u00ae) in the treatment of partial thickness burns. In this two\u2010arm open label multicenter randomized controlled trial, adult patients with acute partial thickness burns and an affected <jats:italic>total body surface area<\/jats:italic> of less than 30% were randomized between Flaminal\u00ae Forte and Flamazine\u00ae and followed for 12\u2009months. Dressing changes in the Flamazine\u00ae group were performed daily, and in the Flaminal\u00ae group during the first 3\u2009days post burn and thereafter every other day until complete wound healing or surgery. Forty\u2010one patients were randomly allocated to Flaminal\u00ae Forte and 48 patients to Flamazine\u00ae. The primary outcome was time to wound healing, which did not differ between the groups: median 18\u2009days with Flaminal\u00ae Forte (range 8\u201349\u2009days) versus 16\u2009days with Flamazine\u00ae (range 7\u201348\u2009days; <jats:italic>p<\/jats:italic>\u2009=\u20090.24). Regarding the secondary outcomes during hospital admission, there were no statistically significant differences between the groups concerning need for surgery, pain scores, pruritus, or pain\u2010related and anticipatory anxiety. More patients in the Flaminal\u00ae group developed wound colonization (78% versus 32%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but the treatment groups did not differ regarding the incidence of local infections and use of systemic antibiotics. In terms of scar quality, no statistically significant differences between both treatment groups were found regarding subjective scar assessment (Patient and Observer Scar Assessment Scale (POSAS)), scar melanin and pigmentation (DermaSpectrometer\u00ae), and scar elasticity and maximal extension (Cutometer\u00ae) during 12\u2009month postburn. In conclusion, time to wound healing did not differ, but the use of Flaminal\u00ae Forte seemed favorable because less dressing changes are needed which lowers the burden of wound care.<\/jats:p>","DOI":"10.1111\/wrr.12699","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T20:13:07Z","timestamp":1548360787000},"page":"257-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Flaminal\u00ae versus Flamazine\u00ae in the treatment of partial thickness burns: A randomized controlled trial on clinical effectiveness and scar quality (FLAM study)"],"prefix":"10.1111","volume":"27","author":[{"given":"Zjir M.","family":"Rashaan","sequence":"first","affiliation":[{"name":"Department of Surgery Leiden University Medical Centre  Leiden The Netherlands"},{"name":"Department of Surgery Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Burn Centre Red Cross Hospital  Beverwijk The 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