{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:56:13Z","timestamp":1789239373301,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004048","name":"KAUMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was carried out to determine the effects of magnesium and vitamin E co\u2010supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double\u2010blind, placebo\u2010controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250\u2009mg magnesium oxide plus 400\u2009IU vitamin E (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929) or placebo per day (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928) for 12\u2009weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    [difference in the mean of outcomes measures between treatment groups] \u22120.56\u2009cm; 95% CI, \u22120.92, \u22120.20;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), width (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22120.35\u2009cm; 95% CI, \u22120.64, \u22120.05;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and depth (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22120.18\u2009cm; 95% CI, \u22120.33, \u22120.02;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). In addition, co\u2010supplementation led to a significant reduction in fasting plasma glucose (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u221213.41\u2009mg\/dL; 95% CI, \u221220.96, \u22125.86;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), insulin (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22121.45 \u03bcIU\/ml; 95% CI, \u22122.37, \u22120.52;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), insulin resistance (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22120.60; 95% CI, \u22120.99, \u22120.20;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) and HbA1c (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22120.32%; 95% CI, \u22120.48, \u22120.16;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.003), and a significant elevation in insulin sensitivity (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    0.007; 95% CI, 0.003, 0.01;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u221210.08\u2009mg\/dL; 95% CI, \u221219.70, \u22120.46;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), LDL\u2010cholesterol (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22125.88\u2009mg\/dL; 95% CI, \u221211.42, \u22120.34;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), high sensitivity C\u2010reactive protein (hs\u2010CRP) (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22123.42\u2009mg\/L; 95% CI, \u22124.44, \u22122.41;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and malondialdehyde (MDA) (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u22120.30\u2009\u03bcmol\/L; 95% CI, \u22120.45, \u22120.15;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and increased HDL\u2010cholesterol (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    2.62\u2009mg\/dL; 95% CI, 0.60, 4.63;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and total antioxidant capacity (TAC) levels (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    53.61\u2009mmol\/L; 95% CI, 4.65, 102.57;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Overall, magnesium and vitamin E co\u2010supplementation for 12\u2009weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL\u2010 and HDL\u2010cholesterol, hs\u2010CRP, TAC, and MDA levels.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12701","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T23:29:30Z","timestamp":1548718170000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The effects of magnesium and vitamin E co\u2010supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"27","author":[{"given":"Hassan","family":"Afzali","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, School of Medicine Kashan University of Medical Sciences  Kashan 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