{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:08:38Z","timestamp":1779192518534,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471068"],"award-info":[{"award-number":["81471068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270926"],"award-info":[{"award-number":["81270926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sirtuin 6 (Sirt6) is an NAD+\u2010dependent deacetylase that regulates central metabolic functions such as glucose homeostasis, fat metabolism, and cell apoptosis. However, the tissue\u2010specific function of Sirt6 in liver regeneration remains unknown. Here, we show that liver\u2010specific Sirt6 knockout (Sirt6LKO) impaired liver reconstitution after 2\/3 partial hepatectomy, which was attributed to an alteration of cell cycle progression. Sirt6 LKO delayed hepatocyte transition into S phase during liver regeneration, as shown by the analysis of cell cycle\u2010related proteins and the immuno staining of Ki\u201067 and 5\u2010bromo\u20102\u2010deoxyuridine (BrdU). The delayed cell cycle in Sirt6 LKO mice was attributed to the disruption of m\u2010TOR and Akt activity, which is an important pro\u2010proliferation pathway in liver regeneration. Sirt6 LKO also reduced carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced liver damage. Our results suggest that Sirt6 LKO impaired liver regeneration via delayed cell cycle and impaired m\u2010TOR and Akt activity.<\/jats:p>","DOI":"10.1111\/wrr.12703","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T07:56:40Z","timestamp":1549007800000},"page":"366-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Liver\u2010specific Sirtuin6 ablation impairs liver regeneration after 2\/3 partial hepatectomy"],"prefix":"10.1111","volume":"27","author":[{"given":"Qinhui","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pharmacy and Adverse Drug Reaction  Chengdu Sichuan, 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyun","family":"Pu","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacy and Adverse Drug Reaction  Chengdu Sichuan, 610041 China"},{"name":"Department of Pharmacy, State 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