{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:37:15Z","timestamp":1787701035985,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24OD019813\u20133"],"award-info":[{"award-number":["R24OD019813\u20133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transplantation of human xenografts onto immunocompromised mice is a powerful research tool for studying wound healing. However, differences in healing between humans and mice and their small size limit this model. We determined whether human cadaver skin xenografts transplanted onto pigs with severe combined immune deficiency (SCID) would survive and not be rejected. Meshed (1:1.5), cryopreserved human cadaver skin was transplanted onto 10 partial thickness dermatome wounds in each of two normal domestic pigs and two SCID pigs. Autografts (<jats:italic>n<\/jats:italic>\u2009=\u20092\/animal) from the four animals were used as controls. In normal pigs, all autografts were engrafted and healed with a minimal, if any, inflammation and scarring. All human xenografts were rejected by the normal pigs within 5\u201311\u2009days and associated with an intense T\u2010cell inflammatory response. In contrast, both autografts and xenografts were engrafted and survived the 28\u2010day study in the SCID pigs with a minimal inflammation and no gross scarring.<\/jats:p>","DOI":"10.1111\/wrr.12715","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T06:44:46Z","timestamp":1551941086000},"page":"426-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Survival of human cadaver skin on severe combined immune deficiency pigs: Proof of concept"],"prefix":"10.1111","volume":"27","author":[{"given":"Adam J.","family":"Singer","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Stony Brook University  Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tuggle","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Animal Science Iowa State University  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Stony Brook University  Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Tredget","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Alberta University  Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Ben Gurion University  Beer\u2010Sheba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7452.1329"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199709000-00021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197104000-00012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37318"},{"key":"e_1_2_7_6_1","first-page":"105","article-title":"Skin grafts in nude mice. 3. Fate of grafts from man and donors of other taxonomic classes","volume":"82","author":"Rygaard J","year":"1974","journal-title":"Acta Pathol Microbiol Scand A."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.29245\/2572-9411\/2017\/3.1103"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812457790"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501132"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-76"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677217750691"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(99)00169-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-198709000-00006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000244828.80490.62"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2012.00856.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_5"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:39:56Z","timestamp":1694381996000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/wrr.12715"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12715","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}