{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:56:16Z","timestamp":1768038976105,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_179213"],"award-info":[{"award-number":["310030_179213"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII3_147675"],"award-info":[{"award-number":["CRSII3_147675"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The zebrafish is a vertebrate organism capable of regenerating many of its organs. Notably, it can undergo epimorphic regeneration of its fins after amputation. This process occurs through the formation of a wound epithelium and the dedifferentiation of mesenchymal and bone\u2010forming cells, which form a proliferative blastema. Here, we report that the entry into the regenerative process involves the local synthesis of serotonin (5\u2010hydroxytryptamine, 5\u2010HT) in the injury\u2010associated tissue. One day after wounding, intracellular accumulation of serotonin was induced in the stump below the amputation plane. During blastema formation, serotonin was detected in the mesenchyme at the vicinity of the amputation plane and in the apical wound epithelium. During the advanced outgrowth phase, this monoamine was no longer present in the blastema, suggesting a temporal involvement of serotonin in the postinjury area. We show the expression of two serotonin synthesizing enzymes, <jats:italic>tryptophan hydroxylase 1a<\/jats:italic> and <jats:italic>1b<\/jats:italic> in the blastema, suggesting the local production of this monoamine. Neither depletion of serotonin by chemical inhibition of tryptophan hydroxylase, nor ectopic administration of this monoamine affected fin regeneration, indicating it does not play a role during this process. Finally, we found that the presence of serotonin during regeneration depends on fibroblast growth factor and retinoic acid signaling. Overall, our study demonstrates that the initiation of fin regeneration is associated with a transient synthesis of serotonin in the regrowing tissue.<\/jats:p>","DOI":"10.1111\/wrr.12719","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:53:51Z","timestamp":1556121231000},"page":"375-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Zebrafish fin regeneration involves transient serotonin synthesis"],"prefix":"10.1111","volume":"27","author":[{"given":"D\u00e9sir\u00e9e","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Department of Biology University of Fribourg  Chemin du Mus\u00e9e 10, 1700, Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ja\u017awi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biology University of Fribourg  Chemin du Mus\u00e9e 10, 1700, Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.04.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4644"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.064717"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.04.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15151"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.33"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2015.03.012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098459"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12861-014-0049-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1964"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21533"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnpit.2017.00400"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn300154j"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1839"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.03.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.074575"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2011.03.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.134817"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.155655"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02101"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117637"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.07.024"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22352"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/genetics\/141.4.1583","article-title":"Temperature\u2010sensitive mutations that cause stage\u2010specific defects in zebrafish fin regeneration","volume":"141","author":"Johnson SL","year":"1995","journal-title":"Genetics"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113350109"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.08.072"},{"key":"e_1_2_6_28_1","first-page":"53","volume-title":"Serotonin: Biosynthesis, Regulation and Health Implications","author":"Maximino C","year":"2013"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.03.006"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9722"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.07.019"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.078543"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165497"},{"key":"e_1_2_6_34_1","first-page":"139","article-title":"Roles for 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