{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:15:17Z","timestamp":1792293317912,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Enhanced and prolonged expression of tumor necrosis factor alpha (TNF\u2010\u03b1), a potent pro\u2010inflammatory cytokine is evidenced during the chronic wound healing process of infected diabetic foot ulcer (IDFU). B\u2010cell activating factor (BAFF) is the member of TNF\u2010\u03b1 family, which implicit in B\u2010cell dysfunction. This study was aimed to evaluate the role of BAFF in diabetic foot ulcer (DFU) patients and to correlate its association with other family of inflammatory cytokines. Circulating levels of BAFF and other cytokines were measured in IDFU (<jats:italic>n<\/jats:italic>\u2009=\u200944) and non\u2010IDFU patients (<jats:italic>n<\/jats:italic>\u2009=\u200940) using multiplexed bead\u2010based cytokine immunoassay. A stepwise significant increase was observed in both circulatory BAFF and C\u2010reactive protein (CRP) during the disease progression. The area under the receiver operating characteristic curve (AUC<jats:sub>ROC<\/jats:sub>) for BAFF was found to be high (0.89; [95% CI: 0.73\u20131.0]), when compared to CRP (0.68; [95% CI: 0.61\u20130.76]). Optimum diagnostic cutoff level for BAFF was found to be \u22652.35\u2009pg\/mL with 62.0% sensitivity and 85.7% specificity. Further, BAFF levels showed a significant positive correlation with CRP among IDFU patients. With respect to other family cytokines, BAFF levels were positively correlated with TNF\u2010\u03b1, interferon family cytokines such as IFN\u2010\u03b12, IL\u201028A\/IFN\u2010\u03bb2, IFN\u2010\u03b3, and IL\u201010 family cytokines such as IL\u201019, IL\u201022, and IL\u201026 and negatively correlated with IL\u20106 receptor family such as gp130\/sIL\u20106R\u03b2. Hence, our data suggest that devising therapeutic strategies to reduce the levels of BAFF may contribute in amelioration of IDFU.<\/jats:p>","DOI":"10.1111\/wrr.12720","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T04:10:36Z","timestamp":1556683836000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Circulatory levels of B\u2010cell activating factor of the TNF family in patients with diabetic foot ulcer: Association with disease progression"],"prefix":"10.1111","volume":"27","author":[{"given":"Umapathy","family":"Dhamodharan","sequence":"first","affiliation":[{"name":"Life Science Division SRM Research Institute, SRM University  Kattankulathur, 603 203 Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Teena","sequence":"additional","affiliation":[{"name":"Department of Biotechnology School of 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