{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:44:17Z","timestamp":1790286257224,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of <jats:italic>Calendula officinalis<\/jats:italic> flower extract as monotherapy compared to control for wound healing in vivo. Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus (up to April 2018) with 14 studies meeting the inclusion criteria, comprising 7 animal experiments and 7 clinical trials. Findings from the review on acute wound healing showed faster resolution of the inflammation phase with increased production of granulation tissue in the test groups treated with extract. These findings were consistent in five animal studies and one randomized clinical trial. Chronic wound healing studies were varied. Two clinical control studies on venous ulcers demonstrated decreased ulcer surface area compared to controls. Another randomized clinical trial demonstrated no improvement for the calendula group in diabetic leg ulcer healing. Burn healing similarly showed mixed results. Two animal studies demonstrated a prophylactic effect for the administration of calendula extract prior to burn injury. A randomized clinical trial of patients suffering from partial to full thickness burns demonstrated no benefit for topical application of calendula extract compared to controls. Two randomized clinical trials assessed the potential for extract to prevent acute post radiation dermatitis, with one study showing improvements compared to trolamine, while the other found no improvement compared to aqua gel cream. Animal studies provide moderate evidence for improved recovery from the inflammation phase and increased production of granulation tissue in calendula extract treatment groups. This review identified some evidence for the beneficial effects of <jats:italic>C. officinalis<\/jats:italic> extract for wound healing, consistent with its role in traditional medicine. There is a need for larger, well\u2010designed randomized control trials to assess the effect of calendula on wound healing including complications.<\/jats:p>","DOI":"10.1111\/wrr.12737","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:28:07Z","timestamp":1559230087000},"page":"548-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["A systematic review of <i>Calendula officinalis<\/i> extract for wound healing"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-8901","authenticated-orcid":false,"given":"Or","family":"Givol","sequence":"first","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Plastic and Reconstructive Surgery Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-6775","authenticated-orcid":false,"given":"Rachel","family":"Kornhaber","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Sheba Medical Center  Tel Hashomer Israel"},{"name":"College of Health and Medicine University of Tasmania  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-4384","authenticated-orcid":false,"given":"Denis","family":"Visentin","sequence":"additional","affiliation":[{"name":"College of Health and Medicine University of Tasmania  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-4850","authenticated-orcid":false,"given":"Michelle","family":"Cleary","sequence":"additional","affiliation":[{"name":"College of Health and Medicine University of Tasmania  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0324","authenticated-orcid":false,"given":"Josef","family":"Haik","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Plastic and Reconstructive Surgery Sheba Medical Center  Tel Hashomer Israel"},{"name":"College of Health and Medicine University of Tasmania  Sydney New South Wales Australia"},{"name":"University of Notre Dame Australia  Fremantle Western Australia Australia"},{"name":"Talpiot Leadership Program, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-0887","authenticated-orcid":false,"given":"Moti","family":"Harats","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Plastic and Reconstructive Surgery Sheba Medical Center  Tel Hashomer Israel"},{"name":"University of Notre Dame Australia  Fremantle Western Australia Australia"},{"name":"Talpiot Leadership Program, Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700531"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2004.11.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.11.s2.1.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7453.1427"},{"key":"e_1_2_8_7_1","unstructured":"Wounds International. International best practice\u2010Best practice guidelines: effective skin and wound management of non\u2010complex burns. 2014. Available athttps:\/\/www.woundsinternational.com\/uploads\/resources\/5ebace6c70d4ea53a5d3e28ca65f1b74.pdf. Accessed January 15 2019."},{"key":"e_1_2_8_8_1","article-title":"Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): a review","volume":"8","author":"Muley B","year":"2009","journal-title":"Trop J Pharmaceut Res"},{"key":"e_1_2_8_9_1","first-page":"236","article-title":"Calendula officinalis and wound healing: a systematic review","volume":"20","author":"Leach MJ","year":"2008","journal-title":"Wounds: A Compendium Clin Res Practice"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810160233721"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1995.tb06719.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/b515312n"},{"key":"e_1_2_8_14_1","first-page":"673","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton E","year":"2000","journal-title":"Pharmacol Rev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5678"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.12.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/375671"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.12.732"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.120520"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5293"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1394940"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502011000100005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_8_25_1","volume-title":"Joanna Briggs institute Reviewer's manual","author":"Tufanaru C","year":"2017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1206389"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/850"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008043"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/JBCPP.2009.20.1.73"},{"key":"e_1_2_8_30_1","first-page":"9","article-title":"Controlled study of three ointments for the local management of 2nd and 3rd degree burns","volume":"28","author":"Lievre M","year":"1992","journal-title":"Clin Trials Metaanal"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.063"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2012.11.003"},{"key":"e_1_2_8_33_1","first-page":"101","article-title":"Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers","volume":"27","author":"Duran V","year":"2005","journal-title":"Int J Tissue React"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0080-623420160000500013"},{"key":"e_1_2_8_35_1","first-page":"279","article-title":"The impact of aloe vera and calendula on perineal healing after episiotomy in primiparous women: a randomized clinical trial","volume":"2","author":"Eghdampour F","year":"2013","journal-title":"J Caring Sci"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/np068016b"},{"key":"e_1_2_8_37_1","first-page":"2167","article-title":"A review on the extraction methods use in medicinal plants, principle, strength and limitation","volume":"4","author":"Azwanida N","year":"2015","journal-title":"Med Aromat Plants"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T04:33:36Z","timestamp":1694320416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/wrr.12737"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12737","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]},"assertion":[{"value":"2019-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}